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CHEBI:9671 - triamterene

Default Structure
ChEBI IDCHEBI:9671
ChEBI Nametriamterene
Stars
DefinitionPteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.
Secondary ChEBI IDCHEBI:93604
Last Modified20 June 2017
DownloadsMolfile
FormulaC12H11N7
Net Charge0
Average Mass253.269
Monoisotopic Mass253.10759
SMILESNc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1
InChIInChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
InChIKeyFNYLWPVRPXGIIP-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
sodium channel blocker  An agent that inhibits sodium influx through cell membranes.
Applications:
hypoglycemic agent  A drug which lowers the blood glucose level.
antiatherosclerotic agent  A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent.
diuretic  An agent that promotes the excretion of urine through its effects on kidney function.
hepatoprotective agent  Any compound that is able to prevent damage to the liver.
cardiovascular drug  A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
ChEBI Ontology
Outgoing Relation(s)
triamterene (CHEBI:9671) has role antiatherosclerotic agent (CHEBI:145947)
triamterene (CHEBI:9671) has role antihypertensive agent (CHEBI:35674)
triamterene (CHEBI:9671) has role cardiovascular drug (CHEBI:35554)
triamterene (CHEBI:9671) has role diuretic (CHEBI:35498)
triamterene (CHEBI:9671) has role hepatoprotective agent (CHEBI:62868)
triamterene (CHEBI:9671) has role hypoglycemic agent (CHEBI:35526)
triamterene (CHEBI:9671) has role sodium channel blocker (CHEBI:38633)
triamterene (CHEBI:9671) is a pteridines (CHEBI:26373)
IUPAC Name 
6-phenylpteridine-2,4,7-triamine
INNs  Source
triamterenaChemIDplus
triamtereneChemIDplus
triamterenoWHO MedNet
triamterenumChemIDplus
Synonyms  Source
NSC-639359ChEMBL
NSC-77625ChEMBL
SK-8542ChEMBL
SK&F 8542ChEMBL
SK&F-8542ChEMBL
Brand Names  Source
DyreniumChEMBL
DytacChEMBL
Triamterene component of dyazideChEMBL
Triamterene component of maxzideChEMBL
Manual XrefsDatabases
2728DrugCentral
D00386KEGG DRUG
LSM-4060LINCS
TriamtereneWikipedia
Registry NumbersSources
CAS:396-01-0ChemIDplus
Citations