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CHEBI:9613 - tolazamide

Default Structure
ChEBI IDCHEBI:9613
ChEBI Nametolazamide
Stars
DefinitionAn N-sulfonylurea that is 1-tosylurea in which a hydrogen attached to the nitrogen at position 3 is replaced by an azepan-1-yl group. A hypoglycemic agent, it is used for the treatment of type 2 diabetes mellitus.
Last Modified22 February 2017
DownloadsMolfile
FormulaC14H21N3O3S
Net Charge0
Average Mass311.407
Monoisotopic Mass311.13036
SMILESCc1ccc(S(=O)(=O)NC(=O)NN2CCCCCC2)cc1
InChIInChI=1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18)
InChIKeyOUDSBRTVNLOZBN-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
potassium channel blocker  An agent that inhibits cell membrane glycoproteins that are selectively permeable to potassium ions.
Application:
hypoglycemic agent  A drug which lowers the blood glucose level.
ChEBI Ontology
Outgoing Relation(s)
tolazamide (CHEBI:9613) has role hypoglycemic agent (CHEBI:35526)
tolazamide (CHEBI:9613) has role potassium channel blocker (CHEBI:50509)
tolazamide (CHEBI:9613) is a N-sulfonylurea (CHEBI:76983)
IUPAC Name 
N-(azepan-1-ylcarbamoyl)-4-methylbenzenesulfonamide
INNs  Source
tolazamidaWHO MedNet
tolazamideWHO MedNet
tolazamideWHO MedNet
tolazamidumWHO MedNet
Synonyms  Source
1-(hexahydro-1-azepinyl)-3-p-tolylsulfonylureaChemIDplus
1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)ureaChemIDplus
4-(p-tolylsulfonyl)-1,1-hexamethylenesemicarbazideChemIDplus
BRN 1323565ChemIDplus
CCRIS 591ChemIDplus
EINECS 214-588-3ChemIDplus
Brand Names  Source
DiabewasChemIDplus
NorglycinChemIDplus
TolinaseKEGG DRUG
Manual XrefsDatabases
2694DrugCentral
D00379KEGG DRUG
DB00839DrugBank
GB887886Patent
HMDB0014977HMDB
LSM-2699LINCS
TolazamideWikipedia
Registry NumbersSources
Reaxys:1323565Reaxys
CAS:1156-19-0NIST Chemistry WebBook
CAS:1156-19-0ChemIDplus
CAS:1156-19-0KEGG DRUG
Citations