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CHEBI:95073 - ricolinostat

ChEBI IDCHEBI:95073
ChEBI Namericolinostat
Stars
DefinitionA member of the class of pyrimidines that is pyrimidine substituted by diphenylamino and [7-(hydroxyamino)-7-oxoheptyl]aminocarbonyl groups at positions 2 and 5, respectively. It is a histone deacetylase 6 inhibitor with potential antineoplastic activity.
Last Modified21 June 2024
DownloadsMolfile
FormulaC24H27N5O3
Net Charge0
Average Mass433.512
Monoisotopic Mass433.21139
SMILESO=C(CCCCCCNC(=O)c1cnc(N(c2ccccc2)c2ccccc2)nc1)NO
InChIInChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)
InChIKeyQGZYDVAGYRLSKP-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
EC 3.5.1.98 (histone deacetylase) inhibitor  An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Applications:
anti-inflammatory agent  Any compound that has anti-inflammatory effects.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
ricolinostat (CHEBI:95073) has role anti-inflammatory agent (CHEBI:67079)
ricolinostat (CHEBI:95073) has role antineoplastic agent (CHEBI:35610)
ricolinostat (CHEBI:95073) has role apoptosis inducer (CHEBI:68495)
ricolinostat (CHEBI:95073) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
ricolinostat (CHEBI:95073) is a hydroxamic acid (CHEBI:24650)
ricolinostat (CHEBI:95073) is a pyrimidinecarboxamide (CHEBI:48438)
ricolinostat (CHEBI:95073) is a secondary carboxamide (CHEBI:140325)
ricolinostat (CHEBI:95073) is a substituted aniline (CHEBI:48975)
ricolinostat (CHEBI:95073) is a tertiary amino compound (CHEBI:50996)
IUPAC Name 
2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide
INNs  Source
ricolinostatWHO MedNet
ricolinostatWHO MedNet
ricolinostatumWHO MedNet
ricolinostatWHO MedNet
Synonyms  Source
N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)-5-pyrimidinecarboxamideChEBI
ACY-63DrugBank
ACY-1215DrugBank
ACY1215ChEBI
ACY 1215ChEBI
Manual XrefsDatabases
LSM-6324LINCS
AH4PDBeChem
DB12376DrugBank
HMDB0244543HMDB
D10661KEGG DRUG
Registry NumbersSources
CAS:1316214-52-4KEGG DRUG
Citations