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CHEBI:95003 - MST-312

ChEBI IDCHEBI:95003
ChEBI NameMST-312
Stars
DefinitionA member of the class of benzamides that results from the formal condensation of the two amino groups of benzene-1,3-diamine with the carboxylic acid groups of two molar equivalents of 2,3-dihydroxybenzoic acid. It is telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay) and exhibits antineoplastic activity.
Last Modified5 July 2024
DownloadsMolfile
FormulaC20H16N2O6
Net Charge0
Average Mass380.356
Monoisotopic Mass380.10084
SMILESO=C(Nc1cccc(NC(=O)c2cccc(O)c2O)c1)c1cccc(O)c1O
InChIInChI=1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)
InChIKeyMIQUEZGHEJGPJB-UHFFFAOYSA-N
Roles Classification
Biological Roles:
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor  A DNA polymerase inhibitor that interferes with the activity of reverse transcriptase, EC 2.7.7.49, a viral DNA polymerase enzyme that retroviruses need in order to reproduce.
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
MST-312 (CHEBI:95003) has role antineoplastic agent (CHEBI:35610)
MST-312 (CHEBI:95003) has role apoptosis inducer (CHEBI:68495)
MST-312 (CHEBI:95003) has role EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor (CHEBI:59897)
MST-312 (CHEBI:95003) is a benzamides (CHEBI:22702)
MST-312 (CHEBI:95003) is a catechols (CHEBI:33566)
MST-312 (CHEBI:95003) is a secondary carboxamide (CHEBI:140325)
IUPAC Name 
N,N'-benzene-1,3-diylbis(2,3-dihydroxybenzamide)
Synonyms  Source
N,N'-(1,3-phenylene)bis(2,3-dihydroxybenzamide)IUPAC
N-[3-[[(2,3-dihydroxyphenyl)-oxomethyl]amino]phenyl]-2,3-dihydroxybenzamideChEBI
MST312ChEBI
MST 312ChEBI
telomerase inhibitor IXChEBI
N,N'-bis(2,3-dihydroxybenzoyl)-1,3-phenylenediamineChEBI
Manual XrefsDatabases
LSM-6230LINCS
Registry NumbersSources
CAS:368449-04-1ChEBI
Citations