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CHEBI:94701 - (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol
| Formula | C10H12FN5O4 |
| Net Charge | 0 |
| Average Mass | 285.235 |
| Monoisotopic Mass | 285.08733 |
| SMILES | Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O |
| InChI | InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1 |
| InChIKey | HBUBKKRHXORPQB-FJFJXFQQSA-N |
| Roles Classification |
|---|
| Biological Role: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antifibrotic agent Any agent which acts to reduce fibrosis. antipsoriatic A drug used to treat psoriasis. anti-inflammatory agent Any compound that has anti-inflammatory effects. anti-anaemic agent A compound which increases either the number of red cells or the amount of haemoglobin in the blood. antirheumatic drug A drug used to treat rheumatoid arthritis. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol (CHEBI:94701) has role anti-anaemic agent (CHEBI:75835) |
| (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol (CHEBI:94701) has role anti-inflammatory agent (CHEBI:67079) |
| (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol (CHEBI:94701) has role antifibrotic agent (CHEBI:233423) |
| (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol (CHEBI:94701) has role antineoplastic agent (CHEBI:35610) |
| (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol (CHEBI:94701) has role antipsoriatic (CHEBI:50748) |
| (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol (CHEBI:94701) has role antirheumatic drug (CHEBI:35842) |
| (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol (CHEBI:94701) has role immunosuppressive agent (CHEBI:35705) |
| (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol (CHEBI:94701) is a purine nucleoside (CHEBI:26394) |
| INNs | Source |
|---|---|
| fludarabina | WHO MedNet |
| fludarabine | WHO MedNet |
| Synonyms | Source |
|---|---|
| 2-f-araa | ChEMBL |
| 2-fluoro ara-a | ChEMBL |
| 2-fluorovidarabine | ChEMBL |
| fludarabine | ChEMBL |
| Fluradosa | ChEMBL |
| NSC-118218 | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| LSM-5747 | LINCS |
| Citations |
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