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CHEBI:9467 - tetrabenazine
| ChEBI ID | CHEBI:9467 |
| ChEBI Name | tetrabenazine |
| Stars | |
| Definition | A racemate consisting of equal amounts of (3R,11bR)- and (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one. An adrenergic uptake inhibitor, it was formerly used as an antipsychotic, but it is now used mainly for the treatment of various movement disorders including chorea, ballism, dystonias, and tardive dyskinesia. |
| Last Modified | 22 February 2017 |
| Wikipedia |
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| Roles Classification |
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| Biological Role: | adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. |
| Applications: | antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| tetrabenazine (CHEBI:9467) has part (3R,11bR)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one (CHEBI:64029) |
| tetrabenazine (CHEBI:9467) has part (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one (CHEBI:64030) |
| tetrabenazine (CHEBI:9467) has role adrenergic uptake inhibitor (CHEBI:35640) |
| tetrabenazine (CHEBI:9467) has role antipsychotic agent (CHEBI:35476) |
| tetrabenazine (CHEBI:9467) is a racemate (CHEBI:60911) |
| IUPAC Name |
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| rac-(3S,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one |
| INNs | Source |
|---|---|
| tetrabenazina | ChemIDplus |
| tetrabenazine | ChemIDplus |
| tetrabenazinum | ChemIDplus |
| Synonyms | Source |
|---|---|
| Tetrabenazine | KEGG COMPOUND |
| 1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo(a)quinolizin-2-one | ChemIDplus |
| 2-oxo-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzoquinolizine | ChemIDplus |
| 1,2,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-one | NIST Chemistry WebBook |
| Ro 1-9569 | ChemIDplus |
| TBZ | ChEBI |
| Brand Names | Source |
|---|---|
| Nitoman | DrugBank |
| Xenazine | DrugBank |
| Citations |
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