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CHEBI:94573 - zibotentan

Default Structure
ChEBI IDCHEBI:94573
ChEBI Namezibotentan
Stars
DefinitionA member of the class of pyridinesulfonamides that is benzene substituted by 3-[(3-methoxy-5-methylpyrazin-2-yl)sulfamoyl]pyridin-2-yl and 1,3,4-oxadiazol-2-yl groups at positions 1 and 4, respectively. It is an endothelin A receptor antagonist with potential antineoplastic activity.
Last Modified14 June 2024
DownloadsMolfile
FormulaC19H16N6O4S
Net Charge0
Average Mass424.442
Monoisotopic Mass424.09537
SMILESCOc1nc(C)cnc1NS(=O)(=O)c1cccnc1-c1ccc(-c2nnco2)cc1
InChIInChI=1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)
InChIKeyFJHHZXWJVIEFGJ-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
endothelin A receptor antagonist  A endothelin receptor antagonist is a drug which selectively blocks endothelin A receptors.
Applications:
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
hepatoprotective agent  Any compound that is able to prevent damage to the liver.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
endothelin A receptor antagonist  A endothelin receptor antagonist is a drug which selectively blocks endothelin A receptors.
ChEBI Ontology
Outgoing Relation(s)
zibotentan (CHEBI:94573) has role antihypertensive agent (CHEBI:35674)
zibotentan (CHEBI:94573) has role antineoplastic agent (CHEBI:35610)
zibotentan (CHEBI:94573) has role endothelin A receptor antagonist (CHEBI:51452)
zibotentan (CHEBI:94573) has role hepatoprotective agent (CHEBI:62868)
zibotentan (CHEBI:94573) is a 1,3,4-oxadiazoles (CHEBI:46810)
zibotentan (CHEBI:94573) is a aromatic ether (CHEBI:35618)
zibotentan (CHEBI:94573) is a benzenes (CHEBI:22712)
zibotentan (CHEBI:94573) is a phenylpyridine (CHEBI:38193)
zibotentan (CHEBI:94573) is a pyrazines (CHEBI:38314)
zibotentan (CHEBI:94573) is a pyridinesulfonamide (CHEBI:48100)
IUPAC Name 
N-(3-methoxy-5-methylpyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3-sulfonamide
INN  Source
zibotentanWHO MedNet
Synonyms  Source
AZD-4054DrugBank
N-(3-methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamideChEBI
ZD 4054ChEBI
ZD-4054DrugBank
ZD4054DrugBank
Manual XrefsDatabases
D07741KEGG DRUG
DB06629DrugBank
HMDB0260003HMDB
LSM-5453LINCS
ZibotentanWikipedia
Registry NumbersSources
CAS:186497-07-4ChEBI
Citations