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CHEBI:9445 - terazosin
| Formula | C19H25N5O4 |
| Net Charge | 0 |
| Average Mass | 387.440 |
| Monoisotopic Mass | 387.19065 |
| SMILES | COc1cc2nc(N3CCN(C(=O)C4CCCO4)CC3)nc(N)c2cc1OC |
| InChI | InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22) |
| InChIKey | VCKUSRYTPJJLNI-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Role: | alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. |
| Applications: | alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| terazosin (CHEBI:9445) has role antihypertensive agent (CHEBI:35674) |
| terazosin (CHEBI:9445) has role antineoplastic agent (CHEBI:35610) |
| terazosin (CHEBI:9445) has role α-adrenergic antagonist (CHEBI:37890) |
| terazosin (CHEBI:9445) is a furans (CHEBI:24129) |
| terazosin (CHEBI:9445) is a piperazines (CHEBI:26144) |
| terazosin (CHEBI:9445) is a primary amino compound (CHEBI:50994) |
| terazosin (CHEBI:9445) is a quinazolines (CHEBI:38530) |
| Incoming Relation(s) |
| terazosin hydrochloride dihydrate (CHEBI:9446) has part terazosin (CHEBI:9445) |
| IUPAC Name |
|---|
| 6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine |
| INNs | Source |
|---|---|
| terazosin | WHO MedNet |
| terazosina | WHO MedNet |
| térazosine | WHO MedNet |
| terazosinum | WHO MedNet |
| Synonyms | Source |
|---|---|
| 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine | ChemIDplus |
| Terazosin | KEGG COMPOUND |
| Terazosine | KEGG COMPOUND |