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CHEBI:94301 - YK-4-279

ChEBI IDCHEBI:94301
ChEBI NameYK-4-279
Stars
DefinitionA member of the class of indolones that is 1,3-dihydro-2H-indol-2-one substituted by hydroxy, 2-(4-methoxyphenyl)-2-oxoethyl, chloro, and chloro groups at positions 3, 3, 4, and 7, respectively. It blocks RNA helicase A binding to EWS-FLI1, induces apoptosis, and exhibits antineoplastic activity.
Last Modified19 July 2024
DownloadsMolfile
FormulaC17H13Cl2NO4
Net Charge0
Average Mass366.200
Monoisotopic Mass365.02216
SMILESCOc1ccc(C(=O)CC2(O)C(=O)Nc3c(Cl)ccc(Cl)c32)cc1
InChIInChI=1S/C17H13Cl2NO4/c1-24-10-4-2-9(3-5-10)13(21)8-17(23)14-11(18)6-7-12(19)15(14)20-16(17)22/h2-7,23H,8H2,1H3,(H,20,22)
InChIKeyHLXSCTYHLQHQDJ-UHFFFAOYSA-N
Roles Classification
Biological Role:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
YK-4-279 (CHEBI:94301) has role antineoplastic agent (CHEBI:35610)
YK-4-279 (CHEBI:94301) has role apoptosis inducer (CHEBI:68495)
YK-4-279 (CHEBI:94301) is a aromatic ketone (CHEBI:76224)
YK-4-279 (CHEBI:94301) is a indolones (CHEBI:24829)
YK-4-279 (CHEBI:94301) is a monomethoxybenzene (CHEBI:25235)
YK-4-279 (CHEBI:94301) is a organochlorine compound (CHEBI:36683)
YK-4-279 (CHEBI:94301) is a tertiary alcohol (CHEBI:26878)
IUPAC Name 
4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one
Synonyms  Source
YK 4-279LINCS
4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-indol-2-oneChEBI
4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-oneChEBI
YK 4279ChEBI
YK4279ChEBI
Manual XrefsDatabases
DB17428DrugBank
Registry NumbersSources
CAS:1037184-44-3ChEBI
Citations