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CHEBI:94267 - parbendazole

ChEBI IDCHEBI:94267
ChEBI Nameparbendazole
Stars
DefinitionA member of the class of benzimidazoles that is 1H-benzimidazole substituted by (methoxycarbonyl)amino and butyl groups at positions 2 and 5, respectively. It is a potent inhibitor of microtubule assembly and also exhibits anthelminthic activity.
Last Modified19 July 2024
DownloadsMolfile
FormulaC13H17N3O2
Net Charge0
Average Mass247.298
Monoisotopic Mass247.13208
SMILESCCCCc1ccc2nc(NC(=O)OC)nc2c1
InChIInChI=1S/C13H17N3O2/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17)
InChIKeyYRWLZFXJFBZBEY-UHFFFAOYSA-N
Roles Classification
Biological Role:
microtubule-destabilising agent  Any substance that interacts with tubulin to inhibit polymerisation of microtubules.
Applications:
antinematodal drug  A substance used in the treatment or control of nematode infestations.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
anthelminthic drug  Substance intended to kill parasitic worms (helminths).
ChEBI Ontology
Outgoing Relation(s)
parbendazole (CHEBI:94267) has role anthelminthic drug (CHEBI:35443)
parbendazole (CHEBI:94267) has role antinematodal drug (CHEBI:35444)
parbendazole (CHEBI:94267) has role antineoplastic agent (CHEBI:35610)
parbendazole (CHEBI:94267) has role microtubule-destabilising agent (CHEBI:61951)
parbendazole (CHEBI:94267) is a benzimidazoles (CHEBI:22715)
parbendazole (CHEBI:94267) is a carbamate ester (CHEBI:23003)
IUPAC Name 
methyl (5-butyl-1H-benzimidazol-2-yl)carbamate
INNs  Source
parbendazoleWHO MedNet
parbendazolumWHO MedNet
parbendazoleWHO MedNet
parbendazolWHO MedNet
Synonyms  Source
N-(5-butyl-1H-benzimidazol-2-yl)carbamic acid methyl esterChEBI
SKF 29044ChEBI
SKF29044ChEBI
SKF-29044ChEBI
PBZChEBI
SK&F 29044ChEBI
Brand Names  Source
HelmatacChEBI
HelatacChEBI
Manual XrefsDatabases
LSM-4893LINCS
HMDB0256126HMDB
D05365KEGG DRUG
H1CPDBeChem
Registry NumbersSources
CAS:14255-87-9KEGG DRUG
Citations