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CHEBI:9364 - suramin sodium

Default Structure
ChEBI IDCHEBI:9364
ChEBI Namesuramin sodium
Stars
DefinitionAn organic sodium salt that is the hexasodium salt of suramin. It is an FDA approved drug for African sleeping sickness and river blindness.
Last Modified15 October 2021
DownloadsMolfile
FormulaC51H34N6O23S6.6Na
Net Charge0
Average Mass1429.194
Monoisotopic Mass1427.93857
SMILESCc1ccc(C(=O)Nc2ccc(S(=O)(=O)[O-])c3cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)[O-])c5cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c45)ccc3C)c2)c1.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
InChIInChI=1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6
InChIKeyVAPNKLKDKUDFHK-UHFFFAOYSA-H
Roles Classification
Biological Roles:
ryanodine receptor agonist  A ryanodine receptor modulator which activates the receptor. Ryanodine receptors (RyRs) act as selective ion channels, modulating the release of calcium. Activating the receptors causes the release of calcium, so depleting internal calcium and ultimately preventing further muscle contraction.
trypanocidal drug  A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida.
purinergic receptor P2 antagonist  An antagonist at purinergic P2 receptors
EC 2.7.11.13 (protein kinase C) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13).
GABA antagonist  A compound that inhibits the action of γ-aminobutyric acid.
apoptosis inhibitor  Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms.
Applications:
trypanocidal drug  A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
antinematodal drug  A substance used in the treatment or control of nematode infestations.
GABA antagonist  A compound that inhibits the action of γ-aminobutyric acid.
angiogenesis inhibitor  An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
ChEBI Ontology
Outgoing Relation(s)
suramin sodium (CHEBI:9364) has part suramin(6−) (CHEBI:180911)
suramin sodium (CHEBI:9364) has role angiogenesis inhibitor (CHEBI:48422)
suramin sodium (CHEBI:9364) has role antinematodal drug (CHEBI:35444)
suramin sodium (CHEBI:9364) has role antineoplastic agent (CHEBI:35610)
suramin sodium (CHEBI:9364) has role apoptosis inhibitor (CHEBI:68494)
suramin sodium (CHEBI:9364) has role EC 2.7.11.13 (protein kinase C) inhibitor (CHEBI:37700)
suramin sodium (CHEBI:9364) has role GABA antagonist (CHEBI:65259)
suramin sodium (CHEBI:9364) has role GABA-gated chloride channel antagonist (CHEBI:38999)
suramin sodium (CHEBI:9364) has role purinergic receptor P2 antagonist (CHEBI:91079)
suramin sodium (CHEBI:9364) has role ryanodine receptor agonist (CHEBI:67114)
suramin sodium (CHEBI:9364) has role trypanocidal drug (CHEBI:36335)
suramin sodium (CHEBI:9364) is a organic sodium salt (CHEBI:38700)
IUPAC Name 
hexasodium 8,8'-{carbonylbis[iminobenzene-3,1-diylcarbonylimino(4-methylbenzene-3,1-diyl)carbonylimino]}dinaphthalene-1,3,5-trisulfonate
INNs  Source
suramina de sodioWHO MedNet
suramine sodiqueWHO MedNet
suramin sodiumWHO MedNet
suraminum natricumWHO MedNet
Synonyms  Source
8,8'-[ureylenebis[m-phenylene carbonylimino(4-methyl-m-phenylene)carbonylimino]]di(1,3,5-naphthalenetrisulfonic acid) hexasodium saltChEBI
BAY 205ChemIDplus
CI 1003ChemIDplus
CI-1003ChemIDplus
NF 060ChemIDplus
SK 24728ChemIDplus
Brand Names  Source
AntrypolChemIDplus
Bayer 205KEGG DRUG
Fourneau 309ChemIDplus
GermaninChemIDplus
MoranylChemIDplus
NaganinChemIDplus
Manual XrefsDatabases
5167ChemSpider
D00808KEGG DRUG
DBSALT000540DrugBank
US4737521Patent
Registry NumbersSources
CAS:129-46-4ChemIDplus
Citations