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CHEBI:9287 - streptonigrin

ChEBI IDCHEBI:9287
ChEBI Namestreptonigrin
Stars
DefinitionComplex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
Secondary ChEBI IDCHEBI:108632
Last Modified28 July 2014
DownloadsMolfile
FormulaC25H22N4O8
Net Charge0
Average Mass506.471
Monoisotopic Mass506.14376
SMILESCOC1=C(N)C(=O)c2nc(-c3nc(C(=O)O)c(C)c(-c4ccc(OC)c(OC)c4O)c3N)ccc2C1=O
InChIInChI=1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34)
InChIKeyPVYJZLYGTZKPJE-UHFFFAOYSA-N
Roles Classification
Biological Role:
antimicrobial agent  A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
streptonigrin (CHEBI:9287) has role antimicrobial agent (CHEBI:33281)
streptonigrin (CHEBI:9287) has role antineoplastic agent (CHEBI:35610)
streptonigrin (CHEBI:9287) is a pyridines (CHEBI:26421)
streptonigrin (CHEBI:9287) is a quinolone (CHEBI:23765)
IUPAC Name 
5-amino-6-(7-amino-6-methoxy-5,8-dioxo-5,8-dihydroquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpyridine-2-carboxylic acid
INNs  Source
rufocromomycinKEGG DRUG
rufocromomicinaChemIDplus
rufocromomycinumChemIDplus
rufocromomycineChemIDplus
Synonyms  Source
5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acidChemIDplus
StreptonigranChemIDplus
Manual XrefsDatabases
C02081KEGG COMPOUND
D05931KEGG DRUG
C00026485KNApSAcK
Registry NumbersSources
Beilstein:599390Beilstein
Gmelin:1240693Gmelin
CAS:3930-19-6KEGG COMPOUND
CAS:3930-19-6ChemIDplus
Citations