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CHEBI:92670 - LY-2183240

Default Structure
ChEBI IDCHEBI:92670
ChEBI NameLY-2183240
Stars
DefinitionA member of the class of tetrazoles that is 1H-tetrazole substituted by N,N-dimethylcarbonyl and [biphenyl]-4-ylmethyl groups at positions 1 and 5, respectively. It was developed by Eli Lilly as a potent inhibitor of anandamide re-uptake and fatty acid amide hydrolase, the enzyme responsible for degrading anandamide.
Last Modified20 June 2024
DownloadsMolfile
FormulaC17H17N5O
Net Charge0
Average Mass307.357
Monoisotopic Mass307.14331
SMILESCN(C)C(=O)n1nnnc1Cc1ccc(-c2ccccc2)cc1
InChIInChI=1S/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
InChIKeyGZNIYOXWFCDBBJ-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor  An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of fatty acid amide hydrolase (EC 3.5.1.99).
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
Applications:
anxiolytic drug  Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
ChEBI Ontology
Outgoing Relation(s)
LY-2183240 (CHEBI:92670) has role analgesic (CHEBI:35480)
LY-2183240 (CHEBI:92670) has role anxiolytic drug (CHEBI:35474)
LY-2183240 (CHEBI:92670) has role EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor (CHEBI:64033)
LY-2183240 (CHEBI:92670) is a biphenyls (CHEBI:22888)
LY-2183240 (CHEBI:92670) is a tertiary carboxamide (CHEBI:140326)
LY-2183240 (CHEBI:92670) is a tetrazoles (CHEBI:35689)
IUPAC Name 
5-([biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide
Synonyms  Source
5-([1,1'-biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamideChEBI
5-[([1,1'-biphenyl]-4-yl)methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamideIUPAC
N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1-tetrazolecarboxamideChEBI
LY 2183240ChEBI
LY2183240ChEBI
Manual XrefsDatabases
LSM-2839LINCS
LY-2183240Wikipedia
Registry NumbersSources
CAS:874902-19-9ChEBI
Citations