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CHEBI:92670 - LY-2183240

ChEBI IDCHEBI:92670
ChEBI NameLY-2183240
Stars
DefinitionA member of the class of tetrazoles that is 1H-tetrazole substituted by N,N-dimethylcarbonyl and [biphenyl]-4-ylmethyl groups at positions 1 and 5, respectively. It was developed by Eli Lilly as a potent inhibitor of anandamide re-uptake and fatty acid amide hydrolase, the enzyme responsible for degrading anandamide.
Last Modified20 June 2024
DownloadsMolfile
FormulaC17H17N5O
Net Charge0
Average Mass307.357
Monoisotopic Mass307.14331
SMILESCN(C)C(=O)n1nnnc1Cc1ccc(-c2ccccc2)cc1
InChIInChI=1S/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
InChIKeyGZNIYOXWFCDBBJ-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor  An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of fatty acid amide hydrolase (EC 3.5.1.99).
Applications:
analgesic  An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
anxiolytic drug  Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
ChEBI Ontology
Outgoing Relation(s)
LY-2183240 (CHEBI:92670) has role analgesic (CHEBI:35480)
LY-2183240 (CHEBI:92670) has role anxiolytic drug (CHEBI:35474)
LY-2183240 (CHEBI:92670) has role EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor (CHEBI:64033)
LY-2183240 (CHEBI:92670) is a biphenyls (CHEBI:22888)
LY-2183240 (CHEBI:92670) is a tertiary carboxamide (CHEBI:140326)
LY-2183240 (CHEBI:92670) is a tetrazoles (CHEBI:35689)
IUPAC Name 
5-([biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide
Synonyms  Source
N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1-tetrazolecarboxamideChEBI
5-[([1,1'-biphenyl]-4-yl)methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamideIUPAC
LY 2183240ChEBI
LY2183240ChEBI
5-([1,1'-biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamideChEBI
Manual XrefsDatabases
LSM-2839LINCS
LY-2183240Wikipedia
Registry NumbersSources
CAS:874902-19-9ChEBI
Citations