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CHEBI:92369 - SU4312

ChEBI IDCHEBI:92369
ChEBI NameSU4312
Stars
DefinitionA member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
Last Modified28 October 2021
DownloadsMolfile
FormulaC17H16N2O
Net Charge0
Average Mass264.328
Monoisotopic Mass264.12626
SMILESCN(C)c1ccc(C=C2C(=O)Nc3ccccc32)cc1
InChIInChI=1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)
InChIKeyUAKWLVYMKBWHMX-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
vascular endothelial growth factor receptor antagonist  An antagonist at the vascular endothelial growth factor receptor.
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
geroprotector  Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
angiogenesis inhibitor  An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
ChEBI Ontology
Outgoing Relation(s)
SU4312 (CHEBI:92369) has role angiogenesis inhibitor (CHEBI:48422)
SU4312 (CHEBI:92369) has role antineoplastic agent (CHEBI:35610)
SU4312 (CHEBI:92369) has role geroprotector (CHEBI:176497)
SU4312 (CHEBI:92369) has role neuroprotective agent (CHEBI:63726)
SU4312 (CHEBI:92369) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
SU4312 (CHEBI:92369) is a oxindoles (CHEBI:38459)
SU4312 (CHEBI:92369) is a substituted aniline (CHEBI:48975)
SU4312 (CHEBI:92369) is a tertiary amino compound (CHEBI:50996)
IUPAC Name 
3-[4-(dimethylamino)benzylidene]-1,3-dihydro-2H-indol-2-one
Synonyms  Source
SU 4312ChemIDplus
DMBIChemIDplus
3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-oneLINCS
SU-4312ChEBI
3-(4-dimethylamino-benzylidenyl)-2-indolinoneChemIDplus
Manual XrefsDatabases
LSM-2454LINCS
Registry NumbersSources
Reaxys:28935825Reaxys
CAS:5812-07-7ChemIDplus
Citations