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CHEBI:92119 - ryuvidine

ChEBI IDCHEBI:92119
ChEBI Nameryuvidine
Stars
DefinitionA member of the class of benzothiazoles that is 1,3-benzothiazole-4,7-dione substituted by methyl and (4-methylphenyl)amino groups at positions 2 and 5, respectively. It is an inhibitor of CDK4 and SETD8 and exhibits cytotoxicity towards a number of human cancer cell lines.
Last Modified19 June 2024
DownloadsMolfile
FormulaC15H12N2O2S
Net Charge0
Average Mass284.340
Monoisotopic Mass284.06195
SMILESCc1ccc(NC2=CC(=O)c3sc(C)nc3C2=O)cc1
InChIInChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3
InChIKeyHFPLHASLIOXVGS-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cyclin-dependent kinase (EC 2.7.11.22).
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
ryuvidine (CHEBI:92119) has role antineoplastic agent (CHEBI:35610)
ryuvidine (CHEBI:92119) has role EC 2.7.11.22 (cyclin-dependent kinase) inhibitor (CHEBI:82665)
ryuvidine (CHEBI:92119) is a p-quinones (CHEBI:25830)
ryuvidine (CHEBI:92119) is a aminotoluene (CHEBI:22531)
ryuvidine (CHEBI:92119) is a benzothiazoles (CHEBI:37947)
ryuvidine (CHEBI:92119) is a secondary amino compound (CHEBI:50995)
IUPAC Name 
2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione
Synonyms  Source
2-methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledioneChEBI
Cdk4 Inhibitor IIIChEBI
5-(N-(4-methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazoleChEBI
cyclic-dependent kinase 4 inhibitor IIIChEBI
SPS812ChEBI
Manual XrefsDatabases
LSM-2121LINCS
Registry NumbersSources
CAS:265312-55-8ChEBI
Citations