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CHEBI:9207 - sotalol hydrochloride

ChEBI IDCHEBI:9207
ChEBI Namesotalol hydrochloride
Stars
DefinitionA hydrochloride salt that is the monohydrochloride of sotalol. It has both β-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Last Modified28 July 2014
DownloadsMolfile
FormulaC12H20N2O3S.HCl
Net Charge0
Average Mass308.831
Monoisotopic Mass308.09614
SMILESCC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1.Cl
InChIInChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
InChIKeyVIDRYROWYFWGSY-UHFFFAOYSA-N
Roles Classification
Biological Role:
beta-adrenergic antagonist  An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
Applications:
anti-arrhythmia drug  A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
beta-adrenergic antagonist  An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
ChEBI Ontology
Outgoing Relation(s)
sotalol hydrochloride (CHEBI:9207) has part sotalol(1+) (CHEBI:63647)
sotalol hydrochloride (CHEBI:9207) has role anti-arrhythmia drug (CHEBI:38070)
sotalol hydrochloride (CHEBI:9207) has role β-adrenergic antagonist (CHEBI:35530)
sotalol hydrochloride (CHEBI:9207) is a hydrochloride (CHEBI:36807)
IUPAC Name 
N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide hydrochloride
Synonyms  Source
sotalol HClChemIDplus
4'-(1-hydroxy-2-(isopropylamino)ethyl)methanesulfonanilide monohydrochlorideChemIDplus
4-(2-Isopropylamino-1-hydroxyaethyl)methanesulfonailid hydrochloridChemIDplus
isopropylaminohydroxyethylmethanesulfonanilide hydrochlorideChemIDplus
sotalol monohydrochlorideChEBI
N-isopropyl-β-(4-methanesulfonamidophenyl)ethanolamine hydrochlorideChemIDplus
Brand Names  Source
BetapaceKEGG DRUG
Betapace AFDrugBank
Manual XrefsDatabases
D01026KEGG DRUG
DB00489DrugBank
Registry NumbersSources
Reaxys:4279514Reaxys
CAS:959-24-0KEGG COMPOUND
CAS:959-24-0ChemIDplus