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CHEBI:91462 - SU6656

ChEBI IDCHEBI:91462
ChEBI NameSU6656
Stars
DefinitionA member of the class of oxindoles that is 3-methyleneoxindole in which the hydrogeh at position 5 has been replaced by a dimethylaminosulfonyl group and in which one of the hydrogens of the methylene group has been replaced by a 4,5,6,7-tetrahydro-indol-2-yl group. It is a specific inhibitor of Src family kinase.
Secondary ChEBI IDCHEBI:131826
Last Modified25 April 2016
SubmitterGareth Owen
DownloadsMolfile
FormulaC19H21N3O3S
Net Charge0
Average Mass371.462
Monoisotopic Mass371.13036
SMILESCN(C)S(=O)(=O)c1ccc2c(c1)C(=Cc1cc3c(n1)CCCC3)C(=O)N2
InChIInChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)
InChIKeyLOGJQOUIVKBFGH-UHFFFAOYSA-N
Roles Classification
Biological Roles:
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor  An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2).
Aurora kinase inhibitor  Any protein kinase inhibitor that inhibits the action of an Aurora kinase (a group of serine/threonine kinases that are essential for cell proliferation).
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
SU6656 (CHEBI:91462) has role antineoplastic agent (CHEBI:35610)
SU6656 (CHEBI:91462) has role Aurora kinase inhibitor (CHEBI:70770)
SU6656 (CHEBI:91462) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617)
SU6656 (CHEBI:91462) is a oxindoles (CHEBI:38459)
SU6656 (CHEBI:91462) is a sulfonamide (CHEBI:35358)
IUPAC Name 
N,N-dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)indoline-5-sulfonamide
Synonyms  Source
SU 6656ChemIDplus
SU-6656ChEBI
Manual XrefsDatabases
LSM-1219LINCS
Registry NumbersSources
CAS:330161-87-0ChemIDplus
Citations