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CHEBI:91440 - HMN-214

ChEBI IDCHEBI:91440
ChEBI NameHMN-214
Stars
DefinitionAn N-sulfonylcarboxamide that is N-[(4-methoxyphenyl)sulfonyl]acetamide in which the hydrogen of the NH group is substituted by a 2-[(E)-2-(1-oxidopyridin-4-yl)ethenyl]phenyl group. It is a potent inhibitor of polo-like kinase 1 (PLK1) that exhibits antineoplastic activity.
Last Modified25 July 2024
DownloadsMolfile
FormulaC22H20N2O5S
Net Charge0
Average Mass424.478
Monoisotopic Mass424.10929
SMILESCOc1ccc(S(=O)(=O)N(C(C)=O)c2ccccc2/C=C/c2cc[n+]([O-])cc2)cc1
InChIInChI=1S/C22H20N2O5S/c1-17(25)24(30(27,28)21-11-9-20(29-2)10-12-21)22-6-4-3-5-19(22)8-7-18-13-15-23(26)16-14-18/h3-16H,1-2H3/b8-7+
InChIKeyOCKHRKSTDPOHEN-BQYQJAHWSA-N
Roles Classification
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
EC 2.7.11.21 (polo kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of any polo kinase (EC 2.7.11.21).
Applications:
prodrug  A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
HMN-214 (CHEBI:91440) has role antineoplastic agent (CHEBI:35610)
HMN-214 (CHEBI:91440) has role apoptosis inducer (CHEBI:68495)
HMN-214 (CHEBI:91440) has role EC 2.7.11.21 (polo kinase) inhibitor (CHEBI:145425)
HMN-214 (CHEBI:91440) has role prodrug (CHEBI:50266)
HMN-214 (CHEBI:91440) is a N-sulfonylcarboxamide (CHEBI:90852)
HMN-214 (CHEBI:91440) is a monomethoxybenzene (CHEBI:25235)
HMN-214 (CHEBI:91440) is a olefinic compound (CHEBI:78840)
HMN-214 (CHEBI:91440) is a pyridine N-oxides (CHEBI:38189)
IUPAC Name 
N-[(4-methoxyphenyl)sulfonyl]-N-{2-[(E)-2-(1-oxidopyridin-4-yl)ethenyl]phenyl}acetamide
Synonyms  Source
HMN214ChEBI
HMN 214ChEBI
IVX214ChEBI
IVX-214ChEBI
IVX 214ChEBI
(E)-4-[2-[2-(N-acetyl-N-[4-methoxybenzenesulfonyl]amino)stilbazole]]1-oxideChEBI
Manual XrefsDatabases
LSM-1192LINCS
Registry NumbersSources
CAS:173529-46-9ChEBI
Citations