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CHEBI:91435 - linifanib

Default Structure
ChEBI IDCHEBI:91435
ChEBI Namelinifanib
Stars
DefinitionA member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 2-fluoro-5-methylphenyl group, while the other is substituted by a p-(3-amino-1H-indazol-4-yl)phenyl group. It is a potent, selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinases.
Last Modified10 December 2016
DownloadsMolfile
FormulaC21H18FN5O
Net Charge0
Average Mass375.407
Monoisotopic Mass375.14954
SMILESCc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4nnc(N)c34)cc2)c1
InChIInChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
InChIKeyMPVGZUGXCQEXTM-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor  An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
Applications:
ophthalmology drug  Any compound used for the treatment of eye conditions or eye diseases.
angiogenesis inhibitor  An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
linifanib (CHEBI:91435) has role angiogenesis inhibitor (CHEBI:48422)
linifanib (CHEBI:91435) has role antineoplastic agent (CHEBI:35610)
linifanib (CHEBI:91435) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
linifanib (CHEBI:91435) has role ophthalmology drug (CHEBI:66981)
linifanib (CHEBI:91435) is a aromatic amine (CHEBI:33860)
linifanib (CHEBI:91435) is a indazoles (CHEBI:38769)
linifanib (CHEBI:91435) is a phenylureas (CHEBI:134043)
INNs  Source
linifanibWHO MedNet
linifanibWHO MedNet
linifanibWHO MedNet
linifanibumWHO MedNet
Synonyms  Source
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)ureaLINCS
A-741439ChEMBL
ABT 869ChemIDplus
ABT-869ChemIDplus
ABT869ChEBI
AL-39324ChEMBL
Manual XrefsDatabases
D09635KEGG DRUG
LinifanibWikipedia
LSM-1183LINCS
Registry NumbersSources
Reaxys:11008713Reaxys
CAS:796967-16-3ChemIDplus
CAS:796967-16-3KEGG DRUG
Citations