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CHEBI:91418 - foretinib
| Formula | C34H34F2N4O6 |
| Net Charge | 0 |
| Average Mass | 632.664 |
| Monoisotopic Mass | 632.24464 |
| SMILES | COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 |
| InChI | InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42) |
| InChIKey | CXQHYVUVSFXTMY-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | c-Met tyrosine kinase inhibitor An EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor that interferes with the action of c-Met tyrosine kinase. vascular endothelial growth factor receptor antagonist An antagonist at the vascular endothelial growth factor receptor. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. |
| Application: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| foretinib (CHEBI:91418) has role antineoplastic agent (CHEBI:35610) |
| foretinib (CHEBI:91418) has role apoptosis inducer (CHEBI:68495) |
| foretinib (CHEBI:91418) has role c-Met tyrosine kinase inhibitor (CHEBI:90199) |
| foretinib (CHEBI:91418) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207) |
| foretinib (CHEBI:91418) is a aromatic ether (CHEBI:35618) |
| foretinib (CHEBI:91418) is a cyclopropanes (CHEBI:51454) |
| foretinib (CHEBI:91418) is a dicarboxylic acid diamide (CHEBI:35779) |
| foretinib (CHEBI:91418) is a monofluorobenzenes (CHEBI:83575) |
| foretinib (CHEBI:91418) is a morpholines (CHEBI:38785) |
| foretinib (CHEBI:91418) is a quinolines (CHEBI:26513) |
| IUPAC Name |
|---|
| N1-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinolin-4-yl}oxy)phenyl]-N'1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide |
| INNs | Source |
|---|---|
| foretinib | WHO MedNet |
| foretinib | WHO MedNet |
| forétinib | WHO MedNet |
| foretinibum | WHO MedNet |
| Synonyms | Source |
|---|---|
| 1-N'-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | ChEBI |
| N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide | ChEBI |
| N-[3-fluoro-4-[[6-(methyloxy)-7-[[3-(morpholin-4-yl)propyl]oxy]quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | ChEBI |
| EXEL 2880 | ChEBI |
| EXEL-2880 | DrugBank |
| EXEL2880 | ChEBI |
| Citations |
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