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CHEBI:91418 - foretinib
| Formula | C34H34F2N4O6 |
| Net Charge | 0 |
| Average Mass | 632.664 |
| Monoisotopic Mass | 632.24464 |
| SMILES | COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 |
| InChI | InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42) |
| InChIKey | CXQHYVUVSFXTMY-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Biological Roles: | vascular endothelial growth factor receptor antagonist An antagonist at the vascular endothelial growth factor receptor. c-Met tyrosine kinase inhibitor An EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor that interferes with the action of c-Met tyrosine kinase. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. |
| Application: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| foretinib (CHEBI:91418) has role antineoplastic agent (CHEBI:35610) |
| foretinib (CHEBI:91418) has role apoptosis inducer (CHEBI:68495) |
| foretinib (CHEBI:91418) has role c-Met tyrosine kinase inhibitor (CHEBI:90199) |
| foretinib (CHEBI:91418) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207) |
| foretinib (CHEBI:91418) is a aromatic ether (CHEBI:35618) |
| foretinib (CHEBI:91418) is a cyclopropanes (CHEBI:51454) |
| foretinib (CHEBI:91418) is a dicarboxylic acid diamide (CHEBI:35779) |
| foretinib (CHEBI:91418) is a monofluorobenzenes (CHEBI:83575) |
| foretinib (CHEBI:91418) is a morpholines (CHEBI:38785) |
| foretinib (CHEBI:91418) is a quinolines (CHEBI:26513) |
| IUPAC Name |
|---|
| N1-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinolin-4-yl}oxy)phenyl]-N'1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide |
| INNs | Source |
|---|---|
| foretinib | WHO MedNet |
| foretinib | WHO MedNet |
| forétinib | WHO MedNet |
| foretinibum | WHO MedNet |
| Synonyms | Source |
|---|---|
| GSK089 | DrugBank |
| XL880 | DrugBank |
| EXEL 2880 | ChEBI |
| XL 880 | DrugBank |
| EXEL2880 | ChEBI |
| GSK1363089 | DrugBank |
| Citations |
|---|