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CHEBI:91367 - AZD-1152

ChEBI IDCHEBI:91367
ChEBI NameAZD-1152
Stars
DefinitionA member of the of quinazolines that is 4-aminoquinazolin-7-ol in which the amino group at position 4 has been substituted by a 5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl group, while the hydroxy group at position 7 has been converted into the corresponding 3-[ethyl(2-hydroxyethyl)aminopropyl ether.
Last Modified17 March 2021
DownloadsMolfile
FormulaC26H30FN7O3
Net Charge0
Average Mass507.570
Monoisotopic Mass507.23942
SMILESCCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)nn3)ncnc2c1
InChIInChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
InChIKeyQYZOGCMHVIGURT-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
Aurora kinase inhibitor  Any protein kinase inhibitor that inhibits the action of an Aurora kinase (a group of serine/threonine kinases that are essential for cell proliferation).
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
AZD-1152 (CHEBI:91367) has role antineoplastic agent (CHEBI:35610)
AZD-1152 (CHEBI:91367) has role Aurora kinase inhibitor (CHEBI:70770)
AZD-1152 (CHEBI:91367) is a anilide (CHEBI:13248)
AZD-1152 (CHEBI:91367) is a monofluorobenzenes (CHEBI:83575)
AZD-1152 (CHEBI:91367) is a primary alcohol (CHEBI:15734)
AZD-1152 (CHEBI:91367) is a pyrazoles (CHEBI:26410)
AZD-1152 (CHEBI:91367) is a quinazolines (CHEBI:38530)
AZD-1152 (CHEBI:91367) is a secondary amino compound (CHEBI:50995)
AZD-1152 (CHEBI:91367) is a secondary carboxamide (CHEBI:140325)
AZD-1152 (CHEBI:91367) is a tertiary amino compound (CHEBI:50996)
Incoming Relation(s)
AZT-1152 (CHEBI:167636) has functional parent AZD-1152 (CHEBI:91367)
IUPAC Name 
2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide
Synonyms  Source
AZD1152ChEBI
AZD-2811ChemIDplus
Manual XrefsDatabases
LSM-1067LINCS
Registry NumbersSources
CAS:722544-51-6ChemIDplus
Citations