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CHEBI:91327 - tivozanib

ChEBI IDCHEBI:91327
ChEBI Nametivozanib
Stars
DefinitionA member of the class of quinolines that is 6,7-dimethoxyquinoline substituted by a 3-chloro-4-{[(5-methyl-1,2-oxazol-3-yl)carbamoyl]amino}phenoxy group at position 4. It is a potent and selective inhibitor of VEGF receptor tyrosine kinases and was previously in clinical development for the treatment of metastatic renal cell carcinoma.
Last Modified19 June 2024
DownloadsMolfile
FormulaC22H19ClN4O5
Net Charge0
Average Mass454.870
Monoisotopic Mass454.10440
SMILESCOc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
InChIInChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
InChIKeySPMVMDHWKHCIDT-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
vascular endothelial growth factor receptor antagonist  An antagonist at the vascular endothelial growth factor receptor.
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
tivozanib (CHEBI:91327) has role antineoplastic agent (CHEBI:35610)
tivozanib (CHEBI:91327) has role apoptosis inducer (CHEBI:68495)
tivozanib (CHEBI:91327) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
tivozanib (CHEBI:91327) is a aromatic ether (CHEBI:35618)
tivozanib (CHEBI:91327) is a isoxazoles (CHEBI:55373)
tivozanib (CHEBI:91327) is a monochlorobenzenes (CHEBI:83403)
tivozanib (CHEBI:91327) is a phenylureas (CHEBI:134043)
tivozanib (CHEBI:91327) is a quinolines (CHEBI:26513)
IUPAC Name 
1-{2-chloro-4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-3-(5-methyl-1,2-oxazol-3-yl)urea
INNs  Source
tivozanibWHO MedNet
tivozanibWHO MedNet
tivozanibumWHO MedNet
tivozanibWHO MedNet
Synonyms  Source
1-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-3-(5-methyl-3-isoxazolyl)ureaChEBI
KIL-8951DrugBank
AV 951DrugBank
KRN 951DrugBank
AV-951DrugBank
KRN-951DrugBank
Manual XrefsDatabases
LSM-1005LINCS
DB11800DrugBank
HMDB0304847HMDB
D09683KEGG DRUG
TivozanibWikipedia
AV9PDBeChem
US7166722Patent
Registry NumbersSources
CAS:475108-18-0KEGG DRUG
Citations