sertindole (CHEBI:9122)

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CHEBI:9122 - sertindole

ChEBI ID	CHEBI:9122
ChEBI Name	sertindole
Stars
Definition	A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-oxoimidazolidin-1-yl)ethyl group.
Last Modified	22 February 2017
Downloads	Molfile

Formula	C24H26ClFN4O
Net Charge	0
Average Mass	440.950
Monoisotopic Mass	440.17792
SMILES	O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1
InChI	InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)
InChIKey	GZKLJWGUPQBVJQ-UHFFFAOYSA-N

Wikipedia

Roles Classification

Biological Roles:

alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

H1-receptor antagonist H₁-receptor antagonists are the drugs that selectively bind to but do not activate histamine H₁ receptors, thereby blocking the actions of endogenous histamine.

serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

Applications:

anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.

H1-receptor antagonist H₁-receptor antagonists are the drugs that selectively bind to but do not activate histamine H₁ receptors, thereby blocking the actions of endogenous histamine.

antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.

second generation antipsychotic Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.

serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

ChEBI Ontology

Outgoing Relation(s)
	sertindole (CHEBI:9122) has role antidepressant (CHEBI:35469)
	sertindole (CHEBI:9122) has role anxiolytic drug (CHEBI:35474)
	sertindole (CHEBI:9122) has role H₁-receptor antagonist (CHEBI:37955)
	sertindole (CHEBI:9122) has role second generation antipsychotic (CHEBI:65191)
	sertindole (CHEBI:9122) has role serotonergic antagonist (CHEBI:48279)
	sertindole (CHEBI:9122) has role α-adrenergic antagonist (CHEBI:37890)
	sertindole (CHEBI:9122) is a heteroarylpiperidine (CHEBI:48585)
	sertindole (CHEBI:9122) is a imidazolidinone (CHEBI:55370)
	sertindole (CHEBI:9122) is a organochlorine compound (CHEBI:36683)
	sertindole (CHEBI:9122) is a organofluorine compound (CHEBI:37143)
	sertindole (CHEBI:9122) is a phenylindole (CHEBI:48559)

IUPAC Name
1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one

INNs	Source
sertindol	ChemIDplus
sertindole	WHO MedNet
sertindole	KEGG DRUG
sertindolum	ChemIDplus

Synonyms	Source
1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one	IUPHAR
Sertindole	KEGG COMPOUND

Brand Names	Source
Serdolect	DrugBank
Serlect	DrugBank
SerLect	KEGG DRUG

Manual Xrefs	Databases
2435	DrugCentral
C07567	KEGG COMPOUND
D00561	KEGG DRUG
DB06144	DrugBank
HMDB0015618	HMDB
LSM-5765	LINCS
Sertindole	Wikipedia

Registry Numbers	Sources
Reaxys:5364890	Reaxys
CAS:106516-24-9	KEGG COMPOUND
CAS:106516-24-9	ChemIDplus

Citations