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CHEBI:91083 - semaxanib

Default Structure
ChEBI IDCHEBI:91083
ChEBI Namesemaxanib
Stars
DefinitionAn oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group.
Last Modified31 March 2022
SubmitterSteve
DownloadsMolfile
FormulaC15H14N2O
Net Charge0
Average Mass238.290
Monoisotopic Mass238.11061
SMILESCc1cc(C)c(/C=C2\C(=O)Nc3ccccc32)n1
InChIInChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
InChIKeyWUWDLXZGHZSWQZ-WQLSENKSSA-N
Wikipedia
Roles Classification
Biological Roles:
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor  An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
vascular endothelial growth factor receptor antagonist  An antagonist at the vascular endothelial growth factor receptor.
Applications:
angiogenesis modulating agent  An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
semaxanib (CHEBI:91083) has functional parent 3-methyleneoxindole (CHEBI:17920)
semaxanib (CHEBI:91083) has role angiogenesis modulating agent (CHEBI:50926)
semaxanib (CHEBI:91083) has role antineoplastic agent (CHEBI:35610)
semaxanib (CHEBI:91083) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
semaxanib (CHEBI:91083) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
semaxanib (CHEBI:91083) is a olefinic compound (CHEBI:78840)
semaxanib (CHEBI:91083) is a oxindoles (CHEBI:38459)
semaxanib (CHEBI:91083) is a pyrroles (CHEBI:26455)
IUPAC Name 
(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
INN  Source
semaxanibKEGG DRUG
Synonyms  Source
3-(1-(3,5-Dimethyl-1H-pyrrol-2-yl)meth-(Z)-ylidene)-2-oxo-2,3-dihydroindoleChemIDplus
3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinoneChEBI
3-((Z)-(3,5-Dimethylpyrrol-2-yl)methylene)-2-indolinoneChemIDplus
SU 5416ChemIDplus
SU5416ChemIDplus
TSU 16ChemIDplus
UniProt Name  Source
semaxanibUniProt
Manual XrefsDatabases
D05819KEGG DRUG
SemaxanibWikipedia
X2MPDBeChem
Registry NumbersSources
Reaxys:7995521Reaxys
CAS:194413-58-6ChemIDplus
CAS:194413-58-6KEGG DRUG
Citations