EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:90932 - cariprazine hydrochloride

ChEBI IDCHEBI:90932
ChEBI Namecariprazine hydrochloride
Stars
DefinitionA hydrochloride obtained by combining cariprazine with one molar equivalent of hydrochloric acid. Used for treatment of schizophrenia and bipolar disorder.
Last Modified13 January 2016
SubmitterSteve
DownloadsMolfile
FormulaC21H32Cl2N4O.HCl
Net Charge0
Average Mass463.881
Monoisotopic Mass462.17199
SMILESCN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1.Cl
InChIInChI=1S/C21H32Cl2N4O.ClH/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23;/h3-5,16-17H,6-15H2,1-2H3,(H,24,28);1H/t16-,17-;
InChIKeyGPPJWWMREQHLQT-BHQIMSFRSA-N
Wikipedia
Roles Classification
Biological Roles:
dopamine agonist  A drug that binds to and activates dopamine receptors.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Applications:
dopamine agonist  A drug that binds to and activates dopamine receptors.
second generation antipsychotic  Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
ChEBI Ontology
Outgoing Relation(s)
cariprazine hydrochloride (CHEBI:90932) has part cariprazine(1+) (CHEBI:90934)
cariprazine hydrochloride (CHEBI:90932) has role dopamine agonist (CHEBI:51065)
cariprazine hydrochloride (CHEBI:90932) has role second generation antipsychotic (CHEBI:65191)
cariprazine hydrochloride (CHEBI:90932) has role serotonergic antagonist (CHEBI:48279)
cariprazine hydrochloride (CHEBI:90932) is a hydrochloride (CHEBI:36807)
IUPAC Name 
N'-(trans-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexyl)-N,N-dimethylurea hydrochloride
Synonyms  Source
cariprazine.HClChEBI
cariprazine monohydrochlorideChEBI
RGH-188 HCLChemIDplus
Brand Name  Source
VraylarKEGG DRUG
Manual XrefsDatabases
D09876KEGG DRUG
CariprazineWikipedia
WO2009104739Patent
EP2251011Patent
US2011059980Patent
DB06016DrugBank
Registry NumbersSources
Reaxys:18784660Reaxys
CAS:1083076-69-0KEGG DRUG
CAS:1083076-69-0ChemIDplus
Citations