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CHEBI:90626 - AMG-208

ChEBI IDCHEBI:90626
ChEBI NameAMG-208
Stars
DefinitionA member of the class of quinolines that is 7-methoxyquinoline substituted at position 4 by a (6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy group. AMG exhibits antitumour activity, particularly in prostate cancer.
Last Modified11 July 2018
Submittermziehm
DownloadsMolfile
FormulaC22H17N5O2
Net Charge0
Average Mass383.411
Monoisotopic Mass383.13822
SMILESCOc1ccc2c(OCc3nnc4ccc(-c5ccccc5)nn34)ccnc2c1
InChIInChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3
InChIKeyHEAIZQNMNCHNFD-UHFFFAOYSA-N
Roles Classification
Biological Role:
c-Met tyrosine kinase inhibitor  An EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor that interferes with the action of c-Met tyrosine kinase.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
AMG-208 (CHEBI:90626) has role antineoplastic agent (CHEBI:35610)
AMG-208 (CHEBI:90626) has role c-Met tyrosine kinase inhibitor (CHEBI:90199)
AMG-208 (CHEBI:90626) is a aromatic ether (CHEBI:35618)
AMG-208 (CHEBI:90626) is a quinolines (CHEBI:26513)
AMG-208 (CHEBI:90626) is a triazolopyridazine (CHEBI:48384)
IUPAC Name 
7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline
Synonyms  Source
AMG208ChEBI
AMG 208ChEBI
Manual XrefsDatabases
L5GPDBeChem
DB08079DrugBank
Registry NumbersSources
CAS:1002304-34-8ChemIDplus
Citations