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CHEBI:90229 - astressin 2B
| ChEBI ID | CHEBI:90229 |
| ChEBI Name | astressin 2B |
| Stars | |
| Definition | A 33-membered homodetic cyclic peptide comprising the sequence Ac-Asp-Leu-Ser-D-Phe-His-α-MeLeu-Leu-Arg-Lys-Nle-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Glu-Asn-Asn-Lys-Leu-Leu-Leu-Asp-α-MeLeu-Ile-NH2 cyclised by an amide bridge, formed by condensation of the side-chain carboxy group of the Glu residue at position 24 and the side-chain amino group of the Lys residue at position 27. |
| Last Modified | 16 November 2015 |
| Submitter | Margaret Duesbury |
| Formula | C183H307N49O53 |
| Net Charge | 0 |
| Average Mass | 4041.692 |
| Monoisotopic Mass | 4039.28339 |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Role: | corticotropin-releasing factor receptor antagonist A hormone antagonist that blocks corticotropin-releasing factor receptors |
| Application: | corticotropin-releasing factor receptor antagonist A hormone antagonist that blocks corticotropin-releasing factor receptors |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| astressin 2B (CHEBI:90229) has role corticotropin-releasing factor receptor antagonist (CHEBI:76977) |
| astressin 2B (CHEBI:90229) is a homodetic cyclic peptide (CHEBI:24613) |
| astressin 2B (CHEBI:90229) is a polypeptide (CHEBI:15841) |
| Synonyms | Source |
|---|---|
| DLSFHLLRKXIEIEKQEKEKQQAENNKLLLDLI | ChEBI |
| Ac-Asp-Leu-Ser-D-Phe-His-α-MeLeu-Leu-Arg-Lys-Nle-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-cyclo-(γ-Glu-Asn-Asn-ε-Lys)-Leu-Leu-Leu-Asp-α-MeLeu-Ile-NH2 | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| Astressin-B | Wikipedia |
| Registry Numbers | Sources |
|---|---|
| CAS:681260-70-8 | ChemIDplus |
| Citations |
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