EMBL-EBI | Chemical Biology | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
CHEBI:8892 - rosiglitazone maleate
| Formula | 2H.C18H19N3O3S.C4H2O4 |
| Net Charge | 0 |
| Average Mass | 473.507 |
| Monoisotopic Mass | 473.12567 |
| SMILES | CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1.O=C([O-])/C=C\C(=O)[O-].[H+].[H+] |
| InChI | InChI=1S/C18H19N3O3S.C4H4O4/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15;5-3(6)1-2-4(7)8/h2-9,15H,10-12H2,1H3,(H,20,22,23);1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | SUFUKZSWUHZXAV-BTJKTKAUSA-N |
| Roles Classification |
|---|
| Biological Roles: | anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antiatherosclerotic agent A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent. insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). hypoglycemic agent A drug which lowers the blood glucose level. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| rosiglitazone maleate (CHEBI:8892) has part rosiglitazone (CHEBI:50122) |
| rosiglitazone maleate (CHEBI:8892) has role anti-HIV agent (CHEBI:64946) |
| rosiglitazone maleate (CHEBI:8892) has role antiatherosclerotic agent (CHEBI:145947) |
| rosiglitazone maleate (CHEBI:8892) has role antineoplastic agent (CHEBI:35610) |
| rosiglitazone maleate (CHEBI:8892) has role cardiovascular drug (CHEBI:35554) |
| rosiglitazone maleate (CHEBI:8892) has role hypoglycemic agent (CHEBI:35526) |
| rosiglitazone maleate (CHEBI:8892) has role insulin-sensitizing drug (CHEBI:50864) |
| rosiglitazone maleate (CHEBI:8892) is a maleate salt (CHEBI:50221) |
| IUPAC Name |
|---|
| 5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione (2Z)-but-2-enedioic acid |
| Synonyms | Source |
|---|---|
| BRL 49653C | ChemIDplus |
| BRL-49653-C | ChEMBL |
| BRL-49653C | ChEMBL |
| NSC-717764 | ChEMBL |
| rosiglitazone maleate | KEGG DRUG |
| Rosiglitzazone maleate | ChEMBL |
| Brand Names | Source |
|---|---|
| Avandia | DrugBank |
| Rosiglitazone maleate component of avandamet | ChEMBL |
| Rosiglitazone maleate component of avandaryl | ChEMBL |
| Registry Numbers | Sources |
|---|---|
| Beilstein:7966066 | Beilstein |
| CAS:155141-29-0 | ChemIDplus |
| Citations |
|---|