EMBL-EBI | Chemical Biology | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
CHEBI:88316 - nefopam
| ChEBI ID | CHEBI:88316 |
| ChEBI Name | nefopam |
| Stars | |
| Definition | A racemate comprising equal amounts of (R)- and (S)-nefopam. The hydrochloride is a centrally acting non-opiate analgesic commonly used for the treatment of moderate to severe pain. |
| Last Modified | 22 February 2017 |
| Submitter | Steve |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Biological Roles: | adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. dopamine uptake inhibitor A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. |
| Applications: | adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. dopamine uptake inhibitor A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| nefopam (CHEBI:88316) has part (R)-nefopam (CHEBI:88323) |
| nefopam (CHEBI:88316) has part (S)-nefopam (CHEBI:88320) |
| nefopam (CHEBI:88316) has role adrenergic uptake inhibitor (CHEBI:35640) |
| nefopam (CHEBI:88316) has role dopamine uptake inhibitor (CHEBI:51039) |
| nefopam (CHEBI:88316) has role non-narcotic analgesic (CHEBI:35481) |
| nefopam (CHEBI:88316) has role serotonin uptake inhibitor (CHEBI:50949) |
| nefopam (CHEBI:88316) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine |
| INNs | Source |
|---|---|
| nefopam | KEGG DRUG |
| nefopamum | ChemIDplus |
| Synonym | Source |
|---|---|
| 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocin | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Reaxys:1217383 | Reaxys |
| CAS:13669-70-0 | KEGG DRUG |
| CAS:13669-70-0 | ChemIDplus |
| Citations |
|---|