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CHEBI:88312 - nefopam hydrochloride
| ChEBI ID | CHEBI:88312 |
| ChEBI Name | nefopam hydrochloride |
| Stars | |
| Definition | A racemate comprising equal amounts of (R)- and (S)-nefopam hydrochloride. A centrally acting non-opiate analgesic commonly used for the treatment of moderate to severe pain. |
| Last Modified | 22 October 2015 |
| Submitter | Steve |
| Formula | C17H20ClNO |
| Net Charge | 0 |
| Average Mass | 289.800 |
| Monoisotopic Mass | 289.12334 |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. dopamine uptake inhibitor A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. |
| Applications: | adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. dopamine uptake inhibitor A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| nefopam hydrochloride (CHEBI:88312) has part (R)-nefopam hydrochloride (CHEBI:88315) |
| nefopam hydrochloride (CHEBI:88312) has part (S)-nefopam hydrochloride (CHEBI:88314) |
| nefopam hydrochloride (CHEBI:88312) has role adrenergic uptake inhibitor (CHEBI:35640) |
| nefopam hydrochloride (CHEBI:88312) has role dopamine uptake inhibitor (CHEBI:51039) |
| nefopam hydrochloride (CHEBI:88312) has role non-narcotic analgesic (CHEBI:35481) |
| nefopam hydrochloride (CHEBI:88312) has role serotonin uptake inhibitor (CHEBI:50949) |
| nefopam hydrochloride (CHEBI:88312) is a racemate (CHEBI:60911) |
| IUPAC Names |
|---|
| rac-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride |
| rac-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocin-5-ium chloride |
| Synonyms | Source |
|---|---|
| 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride | ChemIDplus |
| Nefopam HCl | ChemIDplus |
| (±)-nefopam hydrochloride | ChEBI |
| (RS)-nefopam hydrochloride | ChEBI |
| rac-nefopam hydrochloride | ChEBI |
| Brand Name | Source |
|---|---|
| Acupan | KEGG DRUG |
| Registry Numbers | Sources |
|---|---|
| Reaxys:3575294 | Reaxys |
| CAS:23327-57-3 | KEGG DRUG |
| CAS:23327-57-3 | ChemIDplus |
| Citations |
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