EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:88301 - azaperone

ChEBI IDCHEBI:88301
ChEBI Nameazaperone
Stars
DefinitionAn N-arylpiperazine that is 2-(piperazin-1-yl)pyridine in which the amino hydrogen is replaced by a 3-(4-fluobenzoyl)propyl group. Used mainly as a tranquiliser for pigs and elephants.
Last Modified25 February 2016
SubmitterSteve
DownloadsMolfile
FormulaC19H22FN3O
Net Charge0
Average Mass327.403
Monoisotopic Mass327.17469
SMILESO=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1
InChIInChI=1S/C19H22FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15H2
InChIKeyXTKDAFGWCDAMPY-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
Applications:
antipsychotic agent  Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
ChEBI Ontology
Outgoing Relation(s)
azaperone (CHEBI:88301) has role antipsychotic agent (CHEBI:35476)
azaperone (CHEBI:88301) has role dopaminergic antagonist (CHEBI:48561)
azaperone (CHEBI:88301) is a N-alkylpiperazine (CHEBI:46845)
azaperone (CHEBI:88301) is a N-arylpiperazine (CHEBI:46848)
azaperone (CHEBI:88301) is a aminopyridine (CHEBI:38207)
azaperone (CHEBI:88301) is a aromatic ketone (CHEBI:76224)
azaperone (CHEBI:88301) is a monofluorobenzenes (CHEBI:83575)
azaperone (CHEBI:88301) is a tertiary amino compound (CHEBI:50996)
IUPAC Name 
1-(4-fluorophenyl)-4-[4-(pyridin-2-yl)piperazin-1-yl]butan-1-one
INNs  Source
azaperoneKEGG DRUG
azaperonaChemIDplus
azaperoneChemIDplus
azaperonumChemIDplus
Synonyms  Source
AzaperonChemIDplus
4'-Fluoro-4-(4-(2-pyridyl)-1-piperazinyl)butyrophenoneChemIDplus
1-(3-(4-Fluorobenzoyl)propyl)-4-(2-pyridyl)piperazineChemIDplus
1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanoneNIST Chemistry WebBook
NSC 170976NIST Chemistry WebBook
Brand Name  Source
StresnilKEGG DRUG
Manual XrefsDatabases
D02620KEGG DRUG
AzaperoneWikipedia
LSM-3012LINCS
1871VSDB
Registry NumbersSources
Reaxys:565491Reaxys
CAS:1649-18-9KEGG DRUG
CAS:1649-18-9ChemIDplus
CAS:1649-18-9NIST Chemistry WebBook
Citations