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CHEBI:8774 - ramipril
| Formula | C23H32N2O5 |
| Net Charge | 0 |
| Average Mass | 416.518 |
| Monoisotopic Mass | 416.23112 |
| SMILES | [H][C@@]12CCC[C@]1([H])N(C(=O)[C@H](C)N[C@@H](CCc1ccccc1)C(=O)OCC)[C@H](C(=O)O)C2 |
| InChI | InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1 |
| InChIKey | HDACQVRGBOVJII-JBDAPHQKSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Roles: | Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Brønsted base). Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor An EC 3.4.15.* (peptidyl-dipeptidase) inhibitor that interferes with the action of peptidyl-dipeptidase A (EC 3.4.15.1). bradykinin receptor B2 agonist A bradykinin agonist that binds to and activates bradykinin B2 receptors. antiviral agent A substance that destroys or inhibits replication of viruses. |
| Applications: | hypoglycemic agent A drug which lowers the blood glucose level. renoprotective agent Any compound that is able to prevent damage to the kidneys. cardioprotective agent Any protective agent that is able to prevent damage to the heart. EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor An EC 3.4.15.* (peptidyl-dipeptidase) inhibitor that interferes with the action of peptidyl-dipeptidase A (EC 3.4.15.1). antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. antiatherosclerotic agent A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent. prodrug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. antirheumatic drug A drug used to treat rheumatoid arthritis. anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| ramipril (CHEBI:8774) has role anti-arrhythmia drug (CHEBI:38070) |
| ramipril (CHEBI:8774) has role antiatherosclerotic agent (CHEBI:145947) |
| ramipril (CHEBI:8774) has role antihypertensive agent (CHEBI:35674) |
| ramipril (CHEBI:8774) has role antirheumatic drug (CHEBI:35842) |
| ramipril (CHEBI:8774) has role antiviral agent (CHEBI:22587) |
| ramipril (CHEBI:8774) has role bradykinin receptor B2 agonist (CHEBI:77496) |
| ramipril (CHEBI:8774) has role cardioprotective agent (CHEBI:77307) |
| ramipril (CHEBI:8774) has role cardiovascular drug (CHEBI:35554) |
| ramipril (CHEBI:8774) has role EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (CHEBI:35457) |
| ramipril (CHEBI:8774) has role hypoglycemic agent (CHEBI:35526) |
| ramipril (CHEBI:8774) has role matrix metalloproteinase inhibitor (CHEBI:50664) |
| ramipril (CHEBI:8774) has role prodrug (CHEBI:50266) |
| ramipril (CHEBI:8774) has role renoprotective agent (CHEBI:231911) |
| ramipril (CHEBI:8774) is a azabicycloalkane (CHEBI:38295) |
| ramipril (CHEBI:8774) is a cyclopentapyrrole (CHEBI:38296) |
| ramipril (CHEBI:8774) is a dicarboxylic acid monoester (CHEBI:36244) |
| ramipril (CHEBI:8774) is a dipeptide (CHEBI:46761) |
| ramipril (CHEBI:8774) is a ethyl ester (CHEBI:23990) |
| ramipril (CHEBI:8774) is conjugate acid of ramipril(1−) (CHEBI:231704) |
| Incoming Relation(s) |
| ramipril(1−) (CHEBI:231704) is conjugate base of ramipril (CHEBI:8774) |
| IUPAC Name |
|---|
| (2S,3aS,6aS)-1-[(2S)-2-{[(1S)-1-ethoxycarbonyl-3-phenylpropyl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid |
| INN | Source |
|---|---|
| ramipril | ChemIDplus |
| Synonyms | Source |
|---|---|
| (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid | ChemIDplus |
| Altace (TN) | KEGG DRUG |
| C09AA05 | ChEMBL |
| Cardace | ChEMBL |
| Corpril | ChEMBL |
| Delix | ChEMBL |
| Brand Names | Source |
|---|---|
| Altace | ChEMBL |
| Lopace | ChEMBL |
| Ramipril component of polycap | ChEMBL |
| Ranace | ChEMBL |
| Registry Numbers | Sources |
|---|---|
| Reaxys:4214464 | Reaxys |
| CAS:87333-19-5 | KEGG DRUG |
| CAS:87333-19-5 | ChemIDplus |
| Citations |
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