mycophenolate mofetil (CHEBI:8764)

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CHEBI:8764 - mycophenolate mofetil

ChEBI ID	CHEBI:8764
ChEBI Name	mycophenolate mofetil
Stars
Definition	A carboxylic ester resulting from the formal condensation between the carboxylic acid group of mycophenolic acid and the hydroxy group of 2-(morpholin-4-yl)ethanol. In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases.
Last Modified	23 April 2020
Downloads	Molfile

Formula	C23H31NO7
Net Charge	0
Average Mass	433.501
Monoisotopic Mass	433.21005
SMILES	COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)OCCN1CCOCC1)C(=O)OC2
InChI	InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+
InChIKey	RTGDFNSFWBGLEC-SYZQJQIISA-N

Wikipedia

Roles Classification

Chemical Role:	Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:	anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. antiviral agent A substance that destroys or inhibits replication of viruses. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. EC 1.1.1.205 (IMP dehydrogenase) inhibitor An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD⁺ or NADP⁺ acceptor) inhibitor that interferes with the action of IMP dehydrogenase (EC 1.1.1.205), so blocking de novo biosynthesis of purine nucleotides. antithyroid drug A drug used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.
Applications:	gout suppressant A drug that increases uric acid excretion by the kidney (uricosuric drug), decreases uric acid production (antihyperuricemic), or alleviates the pain and inflammation of acute attacks of gout. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. nephroprotective agent Any protective agent that is able to prevent damage to the kidney. antirheumatic drug A drug used to treat rheumatoid arthritis. antifibrotic agent Any agent which acts to reduce fibrosis. antipsoriatic A drug used to treat psoriasis. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. anti-anaemic agent A compound which increases either the number of red cells or the amount of haemoglobin in the blood. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. hypoglycemic agent A drug which lowers the blood glucose level. anti-inflammatory agent Any compound that has anti-inflammatory effects. renoprotective agent Any compound that is able to prevent damage to the kidneys. prodrug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. antithyroid drug A drug used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.

ChEBI Ontology

Outgoing Relation(s)
	mycophenolate mofetil (CHEBI:8764) has functional parent 2-(morpholin-4-yl)ethanol (CHEBI:67144)
	mycophenolate mofetil (CHEBI:8764) has functional parent mycophenolic acid (CHEBI:168396)
	mycophenolate mofetil (CHEBI:8764) has role anti-anaemic agent (CHEBI:75835)
	mycophenolate mofetil (CHEBI:8764) has role anti-HIV agent (CHEBI:64946)
	mycophenolate mofetil (CHEBI:8764) has role anti-inflammatory agent (CHEBI:67079)
	mycophenolate mofetil (CHEBI:8764) has role anticoronaviral agent (CHEBI:149553)
	mycophenolate mofetil (CHEBI:8764) has role antifibrotic agent (CHEBI:233423)
	mycophenolate mofetil (CHEBI:8764) has role antihypertensive agent (CHEBI:35674)
	mycophenolate mofetil (CHEBI:8764) has role antineoplastic agent (CHEBI:35610)
	mycophenolate mofetil (CHEBI:8764) has role antipsoriatic (CHEBI:50748)
	mycophenolate mofetil (CHEBI:8764) has role antirheumatic drug (CHEBI:35842)
	mycophenolate mofetil (CHEBI:8764) has role antithyroid drug (CHEBI:50671)
	mycophenolate mofetil (CHEBI:8764) has role antiviral agent (CHEBI:22587)
	mycophenolate mofetil (CHEBI:8764) has role cardiovascular drug (CHEBI:35554)
	mycophenolate mofetil (CHEBI:8764) has role EC 1.1.1.205 (IMP dehydrogenase) inhibitor (CHEBI:53746)
	mycophenolate mofetil (CHEBI:8764) has role gout suppressant (CHEBI:35845)
	mycophenolate mofetil (CHEBI:8764) has role hypoglycemic agent (CHEBI:35526)
	mycophenolate mofetil (CHEBI:8764) has role immunosuppressive agent (CHEBI:35705)
	mycophenolate mofetil (CHEBI:8764) has role nephroprotective agent (CHEBI:76595)
	mycophenolate mofetil (CHEBI:8764) has role ophthalmology drug (CHEBI:66981)
	mycophenolate mofetil (CHEBI:8764) has role prodrug (CHEBI:50266)
	mycophenolate mofetil (CHEBI:8764) has role renoprotective agent (CHEBI:231911)
	mycophenolate mofetil (CHEBI:8764) is a carboxylic ester (CHEBI:33308)
	mycophenolate mofetil (CHEBI:8764) is a ether (CHEBI:25698)
	mycophenolate mofetil (CHEBI:8764) is a phenols (CHEBI:33853)
	mycophenolate mofetil (CHEBI:8764) is a tertiary amino compound (CHEBI:50996)
	mycophenolate mofetil (CHEBI:8764) is a γ-lactone (CHEBI:37581)

IUPAC Name
2-(morpholin-4-yl)ethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate

Synonyms	Source
2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate	ChemIDplus
MMF	ChEBI
Mycophenolic acid 2-(4-morpholinyl)ethyl ester	ChEMBL
mycophenolic acid morpholinoethyl ester	ChemIDplus
Mycophenylate mofetil	ChEMBL
Myhibbin	ChEMBL

Brand Names	Source
Arzip	ChEMBL
Cellcept	KEGG DRUG
Mycophenolate mofetil teva	ChEMBL

Manual Xrefs	Databases
1859	DrugCentral
C07908	KEGG COMPOUND
D00752	KEGG DRUG
DB00688	DrugBank
HMDB0014826	HMDB
Mycophenolate_mofetil	Wikipedia

Registry Numbers	Sources
Reaxys:7500599	Reaxys
CAS:128794-94-5	KEGG COMPOUND
CAS:128794-94-5	ChemIDplus

Citations