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CHEBI:8717 - quinethazone

Default Structure
ChEBI IDCHEBI:8717
ChEBI Namequinethazone
Stars
DefinitionA member of the class of quinazolines that is quinazolin-4-one substituted at positions 2, 6 and 7 by ethyl, sulfamoyl and chloro groups respectively; a thiazide-like diuretic used to treat hypertension.
Last Modified19 June 2017
DownloadsMolfile
FormulaC10H12ClN3O3S
Net Charge0
Average Mass289.744
Monoisotopic Mass289.02879
SMILESCCC1NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2N1
InChIInChI=1S/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17)
InChIKeyAGMMTXLNIQSRCG-UHFFFAOYSA-N
Roles Classification
Applications:
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
cardiovascular drug  A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
diuretic  An agent that promotes the excretion of urine through its effects on kidney function.
ChEBI Ontology
Outgoing Relation(s)
quinethazone (CHEBI:8717) has role antihypertensive agent (CHEBI:35674)
quinethazone (CHEBI:8717) has role cardiovascular drug (CHEBI:35554)
quinethazone (CHEBI:8717) has role diuretic (CHEBI:35498)
quinethazone (CHEBI:8717) is a quinazolines (CHEBI:38530)
IUPAC Name 
7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
INN  Source
quinetazonaWHO MedNet
Synonyms  Source
7-chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamideChEBI
NSC-759904ChEMBL
Brand Names  Source
HydromoxChEMBL
Quinethazone component of hydromox rChEMBL
Manual XrefsDatabases
C07342KEGG COMPOUND
D00461KEGG DRUG
LSM-1666LINCS
US9393221Patent
Registry NumbersSources
Reaxys:818554Reaxys
CAS:73-49-4KEGG COMPOUND
Citations