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CHEBI:86290 - 6-bromoindirubin-3'-oxime

ChEBI IDCHEBI:86290
ChEBI Name6-bromoindirubin-3'-oxime
Stars
DefinitionA member of the class of biindoles that is indirubin substituted at position 6 by a bromo group and in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime.
Secondary ChEBI IDCHEBI:47271
Last Modified26 February 2016
SubmitterTheOtherDave
DownloadsMolfile
FormulaC16H10BrN3O2
Net Charge0
Average Mass356.179
Monoisotopic Mass354.99564
SMILESO=C1Nc2cc(Br)ccc2/C1=C1/Nc2ccccc2/C1=N\O
InChIInChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+
InChIKeyDDLZLOKCJHBUHD-WAVHTBQISA-N
Roles Classification
Biological Roles:
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
EC 2.7.11.26 (tau-protein kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of tau-protein kinase inhibitor (EC 2.7.11.26).
ChEBI Ontology
Outgoing Relation(s)
6-bromoindirubin-3'-oxime (CHEBI:86290) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
6-bromoindirubin-3'-oxime (CHEBI:86290) has role EC 2.7.11.26 (tau-protein kinase) inhibitor (CHEBI:91092)
6-bromoindirubin-3'-oxime (CHEBI:86290) is a biindole (CHEBI:48594)
6-bromoindirubin-3'-oxime (CHEBI:86290) is a ketoxime (CHEBI:24983)
6-bromoindirubin-3'-oxime (CHEBI:86290) is a organobromine compound (CHEBI:37141)
6-bromoindirubin-3'-oxime (CHEBI:86290) is a oxindoles (CHEBI:38459)
IUPAC Name 
(3Z)-6-bromo-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Synonyms  Source
(2Z,3E)-6'-bromo-2,3'-biindole-2',3(1H,1'H)-dione 3-oximePDBeChem
(2Z,3E)-6-Bromoindirubin-3'-oximeSUBMITTER
6-BIOSUBMITTER
Manual XrefsDatabases
BRWPDBeChem
Registry NumbersSources
Reaxys:9653830Reaxys
Citations