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CHEBI:85516 - 5'-ATGGACCAAAGAGTTTCAGGGA-3'

ChEBI IDCHEBI:85516
ChEBI Name5'-ATGGACCAAAGAGTTTCAGGGA-3'
Stars
DefinitionA single-stranded DNA oligonucleotide comprised of eight deoxyadenosine, four thymidine, three deoxycytidine and seven deoxyguanosine residues connected by 3'→5' phosphodiester linkages in the sequence ATGGACCAAAGAGTTTCAGGGA. It is a mimic of HuR mRNA nucleotides 671-692 and acts as an antagonist that deregulates human antigen R (HuR) expression and inhibits AKTSER473 phosphorylation in prostate and other cancers.
Last Modified2 March 2022
SubmitterKerry Masterson Ph.D.
DownloadsMolfile
FormulaC217H269N92O126P21
Net Charge0
Average Mass6832.511
Monoisotopic Mass6829.19598
SMILESCc1cn([C@H]2C[C@H](OP(=O)(O)OC[C@H]3O[C@@H](n4cc(C)c(=O)nc4=O)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cc(C)c(=O)nc4=O)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(=O)nc(N)nc54)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(=O)nc(N)nc54)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(N)nc4=O)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(N)nc4=O)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(=O)nc(N)nc54)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(=O)nc(N)nc54)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cc(C)c(=O)nc4=O)C[C@@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)C[C@@H]3O)[C@@H](COP(=O)(O)O[C@H]3C[C@H](n4ccc(N)nc4=O)O[C@@H]3COP(=O)(O)O[C@H]3C[C@H](n4cnc5c(N)ncnc54)O[C@@H]3COP(=O)(O)O[C@H]3C[C@H](n4cnc5c(=O)nc(N)nc54)O[C@@H]3COP(=O)(O)O[C@H]3C[C@H](n4cnc5c(=O)nc(N)nc54)O[C@@H]3COP(=O)(O)O[C@H]3C[C@H](n4cnc5c(=O)nc(N)nc54)O[C@@H]3COP(=O)(O)O[C@H]3C[C@H](n4cnc5c(N)ncnc54)O[C@@H]3CO)O2)c(=O)nc1=O
InChIInChI=1S/C217H269N92O126P21/c1-82-33-291(214(326)284-193(82)312)137-16-91(419-436(330,331)372-38-109-86(311)11-133(394-109)295-67-252-155-170(221)236-59-244-178(155)295)113(398-137)42-380-446(350,351)429-102-27-149(304-76-261-164-187(304)271-205(230)278-198(164)317)412-127(102)56-391-455(368,369)434-106-31-153(308-80-265-168-191(308)275-209(234)282-202(168)321)411-126(106)55-389-449(356,357)427-97-22-144(299-71-256-159-174(225)240-63-248-182(159)299)402-117(97)46-381-440(338,339)418-90-15-136(290-10-7-132(220)269-213(290)325)395-110(90)39-374-438(334,335)416-88-13-134(288-8-5-130(218)267-211(288)323)396-111(88)40-375-444(346,347)423-95-20-142(297-69-254-157-172(223)238-61-246-180(157)297)403-118(95)47-382-447(352,353)425-98-23-145(300-72-257-160-175(226)241-64-249-183(160)300)404-119(98)48-383-448(354,355)426-99-24-146(301-73-258-161-176(227)242-65-250-184(161)301)406-121(99)50-385-453(364,365)432-104-29-151(306-78-263-166-189(306)273-207(232)280-200(166)319)410-125(104)54-388-450(358,359)428-100-25-147(302-74-259-162-177(228)243-66-251-185(162)302)407-122(100)51-386-451(360,361)431-103-28-150(305-77-262-165-188(305)272-206(231)279-199(165)318)409-124(103)53-387-443(344,345)422-94-19-140(294-36-85(4)196(315)287-217(294)329)401-116(94)45-379-442(342,343)421-93-18-139(293-35-84(3)195(314)286-216(293)328)400-115(93)44-378-441(340,341)420-92-17-138(292-34-83(2)194(313)285-215(292)327)399-114(92)43-377-439(336,337)417-89-14-135(289-9-6-131(219)268-212(289)324)397-112(89)41-376-445(348,349)424-96-21-143(298-70-255-158-173(224)239-62-247-181(158)298)405-120(96)49-384-452(362,363)433-105-30-152(307-79-264-167-190(307)274-208(233)281-201(167)320)413-128(105)57-392-456(370,371)435-107-32-154(309-81-266-169-192(309)276-210(235)283-203(169)322)414-129(107)58-390-454(366,367)430-101-26-148(303-75-260-163-186(303)270-204(229)277-197(163)316)408-123(101)52-373-437(332,333)415-87-12-141(393-108(87)37-310)296-68-253-156-171(222)237-60-245-179(156)296/h5-10,33-36,59-81,86-129,133-154,310-311H,11-32,37-58H2,1-4H3,(H,330,331)(H,332,333)(H,334,335)(H,336,337)(H,338,339)(H,340,341)(H,342,343)(H,344,345)(H,346,347)(H,348,349)(H,350,351)(H,352,353)(H,354,355)(H,356,357)(H,358,359)(H,360,361)(H,362,363)(H,364,365)(H,366,367)(H,368,369)(H,370,371)(H2,218,267,323)(H2,219,268,324)(H2,220,269,325)(H2,221,236,244)(H2,222,237,245)(H2,223,238,246)(H2,224,239,247)(H2,225,240,248)(H2,226,241,249)(H2,227,242,250)(H2,228,243,251)(H,284,312,326)(H,285,313,327)(H,286,314,328)(H,287,315,329)(H3,229,270,277,316)(H3,230,271,278,317)(H3,231,272,279,318)(H3,232,273,280,319)(H3,233,274,281,320)(H3,234,275,282,321)(H3,235,276,283,322)/t86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108+,109+,110+,111+,112+,113+,114+,115+,116+,117+,118+,119+,120+,121+,122+,123+,124+,125+,126+,127+,128+,129+,133+,134+,135+,136+,137+,138+,139+,140+,141+,142+,143+,144+,145+,146+,147+,148+,149+,150+,151+,152+,153+,154+/m0/s1
InChIKeyOVUOHXDFTINJHJ-KFBNSSTOSA-N
ChEBI Ontology
Outgoing Relation(s)
5'-ATGGACCAAAGAGTTTCAGGGA-3' (CHEBI:85516) is a single-stranded DNA oligonucleotide (CHEBI:75153)
Synonyms  Source
HPSChEBI
d(ATGGACCAAAGAGTTTCAGGGA)ChEBI
d(A-T-G-G-A-C-C-A-A-A-G-A-G-T-T-T-C-A-G-G-G-A)ChEBI
5'-d[ATGGACCAAAGAGTTTCAGGGA]-3'ChEBI
5'-ApTpGpGpApCpCpApApApGpApGpTpTpTpCpApGpGpGpA-3'ChEBI