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CHEBI:85202 - peramivir

ChEBI IDCHEBI:85202
ChEBI Nameperamivir
Stars
DefinitionA member of the class of guanidines that is used (as its trihydrate) for the treatment of acute uncomplicated influenza in patients 18 years and older who have been symptomatic for no more than two days.
Secondary ChEBI IDCHEBI:41095
Last Modified22 February 2017
SubmitterSteve
DownloadsMolfile
FormulaC15H28N4O4
Net Charge0
Average Mass328.413
Monoisotopic Mass328.21106
SMILES[H][C@@]1([C@@H](NC(C)=O)C(CC)CC)[C@H](O)[C@@H](C(=O)O)C[C@H]1NC(=N)N
InChIInChI=1S/C15H28N4O4/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19)/t9-,10+,11+,12-,13+/m0/s1
InChIKeyXRQDFNLINLXZLB-CKIKVBCHSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Roles:
antiviral drug  A substance used in the prophylaxis or therapy of virus diseases.
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor  An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein (EC 3.2.1.18), thus preventing the virus from budding from the host cell.
Applications:
antiviral drug  A substance used in the prophylaxis or therapy of virus diseases.
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor  An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein (EC 3.2.1.18), thus preventing the virus from budding from the host cell.
ChEBI Ontology
Outgoing Relation(s)
peramivir (CHEBI:85202) has part peramivir hydrate (CHEBI:85196)
peramivir (CHEBI:85202) has role antiviral drug (CHEBI:36044)
peramivir (CHEBI:85202) has role EC 3.2.1.18 (exo-α-sialidase) inhibitor (CHEBI:52425)
peramivir (CHEBI:85202) is a 3-hydroxy monocarboxylic acid (CHEBI:35969)
peramivir (CHEBI:85202) is a acetamides (CHEBI:22160)
peramivir (CHEBI:85202) is a cyclopentanols (CHEBI:23495)
peramivir (CHEBI:85202) is a guanidines (CHEBI:24436)
IUPAC Name 
(1S,2S,3R,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-carbamimidamido-2-hydroxycyclopentane-1-carboxylic acid
Synonyms  Source
RWJ-270201ChemIDplus
RWJ270201ChemIDplus
BCX-1812ChemIDplus
RWJ 270201ChemIDplus
BCX1812ChemIDplus
BCX 1812ChemIDplus
Manual XrefsDatabases
BCZPDBeChem
PeramivirWikipedia
4823DrugCentral
Registry NumbersSources
Reaxys:9011170Reaxys
CAS:330600-85-6ChemIDplus
Citations