EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:8491 - propiomazine

ChEBI IDCHEBI:8491
ChEBI Namepropiomazine
Stars
DefinitionA member of the class of phenothiazines that is 10H-phenothiazine substituted by a 2-(dimethylamino)propyl group at nitrogen atom and a propanoyl group at position 2.
Last Modified22 February 2017
DownloadsMolfile
FormulaC20H24N2OS
Net Charge0
Average Mass340.492
Monoisotopic Mass340.16093
SMILESCCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2
InChIInChI=1S/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3
InChIKeyUVOIBTBFPOZKGP-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
muscarinic antagonist  A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
histamine antagonist  Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
Applications:
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
muscarinic antagonist  A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
sedative  A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
histamine antagonist  Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
ChEBI Ontology
Outgoing Relation(s)
propiomazine (CHEBI:8491) has parent hydride 10H-phenothiazine (CHEBI:37931)
propiomazine (CHEBI:8491) has role dopaminergic antagonist (CHEBI:48561)
propiomazine (CHEBI:8491) has role histamine antagonist (CHEBI:37956)
propiomazine (CHEBI:8491) has role muscarinic antagonist (CHEBI:48876)
propiomazine (CHEBI:8491) has role phenothiazine antipsychotic drug (CHEBI:37930)
propiomazine (CHEBI:8491) has role sedative (CHEBI:35717)
propiomazine (CHEBI:8491) has role serotonergic antagonist (CHEBI:48279)
propiomazine (CHEBI:8491) is a aromatic ketone (CHEBI:76224)
propiomazine (CHEBI:8491) is a phenothiazines (CHEBI:38093)
propiomazine (CHEBI:8491) is a tertiary amino compound (CHEBI:50996)
Incoming Relation(s)
propiomazine hydrochloride (CHEBI:8492) has part propiomazine (CHEBI:8491)
IUPAC Name 
1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}propan-1-one
INNs  Source
propiomazineChEBI
propiomazinaChEBI
propiomazinumChEBI
Synonyms  Source
10-(2-Dimethylaminopropyl)-2-propionylphenothiazineChemIDplus
2-Propionyl-10-(2-(dimethylamino)propyl)phenothiazineChemIDplus
3-Propionyl-10-dimethylaminoisopropylphenothiazineChemIDplus
Manual XrefsDatabases
C07405KEGG COMPOUND
D02361KEGG DRUG
DB00777DrugBank
FR1176919Patent
PropiomazineWikipedia
HMDB0014915HMDB
2298DrugCentral
Registry NumbersSources
Reaxys:39712Reaxys
CAS:362-29-8ChemIDplus