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CHEBI:84491 - poly(I:C)

Default Structure
ChEBI IDCHEBI:84491
ChEBI Namepoly(I:C)
Stars
DefinitionA mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.
Last Modified3 April 2015
SubmitterMarcus Ennis
DownloadsMolfile
Formula(C10H11N4O7P)n.(C9H12N3O7P)n.C38H50N14O30P4
Net Charge0
Average Mass1942.158
Monoisotopic Mass1941.25459
SMILESNc1ccn([C@@H]2O[C@H](COP(=O)(O)O[C@H]3[C@@H](O)[C@H](n4ccc(N)nc4=O)O[C@@H]3COP(=O)(O)O[C@H]3[C@@H](O)[C@H](n4ccc(N)nc4=O)O[C@@H]3COP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)n1.O=c1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O[C@H]2[C@@H](O)[C@H](n3cnc4c(=O)ncnc43)O[C@@H]2COP(=O)(O)O[C@H]2[C@@H](O)[C@H](n3cnc4c(=O)ncnc43)O[C@@H]2COP(=O)(O)O)[C@@H](O)[C@H]1O
InChIInChI=1S/C30H35N12O22P3.C27H38N9O22P3/c43-16-10(60-28(17(16)44)40-7-37-13-22(40)31-4-34-25(13)47)1-58-66(53,54)64-21-12(62-30(19(21)46)42-9-39-15-24(42)33-6-36-27(15)49)3-59-67(55,56)63-20-11(2-57-65(50,51)52)61-29(18(20)45)41-8-38-14-23(41)32-5-35-26(14)48;28-13-1-4-34(25(41)31-13)22-17(38)16(37)10(54-22)7-52-60(47,48)58-21-12(56-24(19(21)40)36-6-3-15(30)33-27(36)43)9-53-61(49,50)57-20-11(8-51-59(44,45)46)55-23(18(20)39)35-5-2-14(29)32-26(35)42/h4-12,16-21,28-30,43-46H,1-3H2,(H,53,54)(H,55,56)(H,31,34,47)(H,32,35,48)(H,33,36,49)(H2,50,51,52);1-6,10-12,16-24,37-40H,7-9H2,(H,47,48)(H,49,50)(H2,28,31,41)(H2,29,32,42)(H2,30,33,43)(H2,44,45,46)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-;10-,11-,12-,16-,17-,18-,19-,20-,21-,22-,23-,24-/m11/s1
InChIKeyINGJKBXWOTWTRP-FRCWJHAJSA-N
Wikipedia
Roles Classification
Biological Role:
immunological adjuvant  A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity.
Application:
immunological adjuvant  A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity.
ChEBI Ontology
Outgoing Relation(s)
poly(I:C) (CHEBI:84491) has part poly(cytidylic acid) (CHEBI:84498)
poly(I:C) (CHEBI:84491) has part poly(inosinic acid) (CHEBI:76777)
poly(I:C) (CHEBI:84491) has role immunological adjuvant (CHEBI:50847)
poly(I:C) (CHEBI:84491) is a double-stranded RNA (CHEBI:67208)
Synonyms  Source
5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acid homopolymer (1:1)ChemIDplus
PI:CChemIDplus
Poly C poly IChemIDplus
Poly(cytidylic acid)-poly(inosinic acid)ChemIDplus
Polycytidylic-polyinosinic acidChemIDplus
poly I:CChEBI
Manual XrefsDatabases
Polyinosinic:polycytidylic_acidWikipedia
Registry NumbersSources
CAS:24939-03-5ChemIDplus
Citations