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CHEBI:8435 - prochlorperazine
| Formula | C20H24ClN3S |
| Net Charge | 0 |
| Average Mass | 373.953 |
| Monoisotopic Mass | 373.13795 |
| SMILES | CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 |
| InChI | InChI=1S/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3 |
| InChIKey | WIKYUJGCLQQFNW-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists. dopamine receptor D2 antagonist An antagonist that binds to and deactivates the dopamine receptor D2, the main receptor for all antipsychotic drugs. EC 3.4.21.26 (prolyl oligopeptidase) inhibitor Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26). dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. |
| Applications: | antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. first generation antipsychotic Antipsychotic drugs which can have different modes of action but which tend to be more likely than second generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements; such body movements can become permanent even after treatment has ceased. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| prochlorperazine (CHEBI:8435) has parent hydride 10H-phenothiazine (CHEBI:37931) |
| prochlorperazine (CHEBI:8435) has role antiemetic (CHEBI:50919) |
| prochlorperazine (CHEBI:8435) has role cholinergic antagonist (CHEBI:48873) |
| prochlorperazine (CHEBI:8435) has role dopamine receptor D2 antagonist (CHEBI:131787) |
| prochlorperazine (CHEBI:8435) has role dopaminergic antagonist (CHEBI:48561) |
| prochlorperazine (CHEBI:8435) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779) |
| prochlorperazine (CHEBI:8435) has role first generation antipsychotic (CHEBI:65190) |
| prochlorperazine (CHEBI:8435) has role α-adrenergic antagonist (CHEBI:37890) |
| prochlorperazine (CHEBI:8435) is a N-alkylpiperazine (CHEBI:46845) |
| prochlorperazine (CHEBI:8435) is a N-methylpiperazine (CHEBI:46920) |
| prochlorperazine (CHEBI:8435) is a organochlorine compound (CHEBI:36683) |
| prochlorperazine (CHEBI:8435) is a phenothiazines (CHEBI:38093) |
| Incoming Relation(s) |
| prochlorperazine maleate (CHEBI:8436) has part prochlorperazine (CHEBI:8435) |
| prochlorperazine methanesulfonate (CHEBI:34932) has part prochlorperazine (CHEBI:8435) |
| IUPAC Name |
|---|
| 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine |
| INNs | Source |
|---|---|
| prochlorperazine | ChEBI |
| prochlorperazinum | ChEBI |
| prochlorpérazine | ChEBI |
| proclorperazina | ChEBI |
| Synonyms | Source |
|---|---|
| Prochlorperazine | KEGG COMPOUND |
| 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine | ChemIDplus |
| 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine | ChemIDplus |
| 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine | ChemIDplus |
| 3-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine | ChemIDplus |
| Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine | ChemIDplus |
| Citations |
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