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CHEBI:83807 - paliperidone palmitate
| ChEBI ID | CHEBI:83807 |
| ChEBI Name | paliperidone palmitate |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)-paliperidone palmitate. A long-acting injectable formulation of paliperidone (the major active metabolite of risperidone) that is used for treatment of schizophrenia. |
| Last Modified | 22 February 2017 |
| Submitter | Steve |
| Formula | C39H57FN4O4 |
| Net Charge | 0 |
| Average Mass | 664.893 |
| Monoisotopic Mass | 664.43638 |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. |
| Applications: | dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. psychotropic drug A loosely defined grouping of drugs that have effects on psychological function. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. second generation antipsychotic Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| paliperidone palmitate (CHEBI:83807) has part (R)-paliperidone palmitate (CHEBI:83810) |
| paliperidone palmitate (CHEBI:83807) has part (S)-paliperidone palmitate (CHEBI:83809) |
| paliperidone palmitate (CHEBI:83807) has role dopaminergic antagonist (CHEBI:48561) |
| paliperidone palmitate (CHEBI:83807) has role H1-receptor antagonist (CHEBI:37955) |
| paliperidone palmitate (CHEBI:83807) has role neuroprotective agent (CHEBI:63726) |
| paliperidone palmitate (CHEBI:83807) has role psychotropic drug (CHEBI:35471) |
| paliperidone palmitate (CHEBI:83807) has role second generation antipsychotic (CHEBI:65191) |
| paliperidone palmitate (CHEBI:83807) has role serotonergic antagonist (CHEBI:48279) |
| paliperidone palmitate (CHEBI:83807) has role α-adrenergic antagonist (CHEBI:37890) |
| paliperidone palmitate (CHEBI:83807) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl hexadecanoate |
| Synonyms | Source |
|---|---|
| RO92670 | ChemIDplus |
| RO 92670 | ChemIDplus |
| paliperidone hexadecanoate | ChEBI |
| (RS)-paliperidone palmitate | ChEBI |
| (±)-paliperidone palmitate | ChEBI |
| rac-paliperidone palmitate | ChEBI |
| Brand Names | Source |
|---|---|
| INVEGA SUSTENNA | KEGG DRUG |
| Xeplion | KEGG DRUG |
| Manual Xrefs | Databases |
|---|---|
| D05340 | KEGG DRUG |
| Paliperidone | Wikipedia |
| Registry Numbers | Sources |
|---|---|
| Reaxys:15026585 | Reaxys |
| CAS:199739-10-1 | KEGG DRUG |
| CAS:199739-10-1 | ChemIDplus |
| Citations |
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