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CHEBI:8379 - prednisolone sodium phosphate

Default Structure
ChEBI IDCHEBI:8379
ChEBI Nameprednisolone sodium phosphate
Stars
DefinitionAn organic sodium salt of prednisolone phosphate. It is an ophthalmology drug used for the treatment of short-term inflammatory eye conditions and helps relieve inflammation, redness and irritation of the eyes.
Last Modified19 December 2019
DownloadsMolfile
FormulaC21H27O8P.2Na
Net Charge0
Average Mass484.393
Monoisotopic Mass484.12389
SMILES[H][C@@]12CC[C@](O)(C(=O)COP(=O)([O-])[O-])[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@@]21C.[Na+].[Na+]
InChIInChI=1S/C21H29O8P.2Na/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-29-30(26,27)28)20(15,2)10-16(23)18(14)19;;/h5,7,9,14-16,18,23,25H,3-4,6,8,10-11H2,1-2H3,(H2,26,27,28);;/q;2*+1/p-2/t14-,15-,16-,18+,19-,20-,21-;;/m0../s1
InChIKeyVJZLQIPZNBPASX-OJJGEMKLSA-L
Wikipedia
Roles Classification
Biological Roles:
immunosuppressive agent  An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
glucocorticoid receptor agonist  An agonist that selectively binds to and activates a glucocorticoid receptor.
hormone  Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
Applications:
anti-asthmatic agent  Any compound that has anti-asthmatic effects.
antifibrotic agent  Any agent which acts to reduce fibrosis.
anti-allergic agent  A drug used to treat allergic reactions.
ophthalmology drug  Any compound used for the treatment of eye conditions or eye diseases.
immunosuppressive agent  An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
anti-inflammatory agent  Any compound that has anti-inflammatory effects.
prodrug  A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
anti-anaemic agent  A compound which increases either the number of red cells or the amount of haemoglobin in the blood.
ChEBI Ontology
Outgoing Relation(s)
prednisolone sodium phosphate (CHEBI:8379) has part prednisolone phosphate(2−) (CHEBI:145706)
prednisolone sodium phosphate (CHEBI:8379) has role anti-allergic agent (CHEBI:50857)
prednisolone sodium phosphate (CHEBI:8379) has role anti-anaemic agent (CHEBI:75835)
prednisolone sodium phosphate (CHEBI:8379) has role anti-asthmatic agent (CHEBI:65023)
prednisolone sodium phosphate (CHEBI:8379) has role anti-inflammatory agent (CHEBI:67079)
prednisolone sodium phosphate (CHEBI:8379) has role antifibrotic agent (CHEBI:233423)
prednisolone sodium phosphate (CHEBI:8379) has role antineoplastic agent (CHEBI:35610)
prednisolone sodium phosphate (CHEBI:8379) has role glucocorticoid receptor agonist (CHEBI:63562)
prednisolone sodium phosphate (CHEBI:8379) has role immunosuppressive agent (CHEBI:35705)
prednisolone sodium phosphate (CHEBI:8379) has role ophthalmology drug (CHEBI:66981)
prednisolone sodium phosphate (CHEBI:8379) has role prodrug (CHEBI:50266)
prednisolone sodium phosphate (CHEBI:8379) is a glucocorticoid (CHEBI:24261)
prednisolone sodium phosphate (CHEBI:8379) is a organic sodium salt (CHEBI:38700)
IUPAC Name 
disodium 11β,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl phosphate
Synonyms  Source
11β,17α-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl phosphate disodiumChEBI
disodium prednisolone 21-phosphateChEBI
NSC-759187ChEMBL
prednisolone 21-disodium phosphateDrugBank
prednisolone 21-phosphate disodiumChemIDplus
prednisolone disodium phosphateChemIDplus
Brand Names  Source
CodelsolChemIDplus
Cortisate-20ChemIDplus
HydeltrasolChemIDplus
InflamaseChemIDplus
Inflamase ForteChemIDplus
Inflamase mildChEMBL
Manual XrefsDatabases
4451DrugCentral
D00981KEGG DRUG
DBSALT000785DrugBank
MX2008015059Patent
Prednisolone_sodium_phosphateWikipedia
Registry NumbersSources
Reaxys:4795229Reaxys
CAS:125-02-0ChemIDplus
Citations