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CHEBI:83404 - G-573

ChEBI IDCHEBI:83404
ChEBI NameG-573
Stars
DefinitionA monocarboxylic acid amide obtained by formal condensation of the carboxy group of 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]furo[3,2-c]pyridine-2-carboxylic acid with the amino group of (2S)-1-(aminooxy)propan-2-ol.
Last Modified9 January 2015
SubmitterMargaret Duesbury
DownloadsMolfile
FormulaC17H14F2IN3O4
Net Charge0
Average Mass489.216
Monoisotopic Mass488.99971
SMILESC[C@H](O)CONC(=O)c1oc2c(F)cncc2c1Nc1ccc(I)cc1F
InChIInChI=1S/C17H14F2IN3O4/c1-8(24)7-26-23-17(25)16-14(10-5-21-6-12(19)15(10)27-16)22-13-3-2-9(20)4-11(13)18/h2-6,8,22,24H,7H2,1H3,(H,23,25)/t8-/m0/s1
InChIKeyZEZHPEIEEFTILY-QMMMGPOBSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24).
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
G-573 (CHEBI:83404) has role antineoplastic agent (CHEBI:35610)
G-573 (CHEBI:83404) has role EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor (CHEBI:79091)
G-573 (CHEBI:83404) is a aromatic amine (CHEBI:33860)
G-573 (CHEBI:83404) is a furopyridine (CHEBI:38197)
G-573 (CHEBI:83404) is a monocarboxylic acid amide (CHEBI:29347)
G-573 (CHEBI:83404) is a organofluorine compound (CHEBI:37143)
G-573 (CHEBI:83404) is a organoiodine compound (CHEBI:37142)
G-573 (CHEBI:83404) is a secondary alcohol (CHEBI:35681)
G-573 (CHEBI:83404) is a secondary amino compound (CHEBI:50995)
IUPAC Name 
7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-[(2S)-2-hydroxypropoxy]furo[3,2-c]pyridine-2-carboxamide
Registry NumbersSources
Reaxys:13101316Reaxys
Citations