EMBL-EBI | Chemical Biology | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
CHEBI:82978 - paliperidone
| ChEBI ID | CHEBI:82978 |
| ChEBI Name | paliperidone |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)-paliperidone. Paliperidone is the primary active metabolite of the older antipsychotic risperidone and is used for treatment of schizophrenia. |
| Last Modified | 22 February 2017 |
| Submitter | tmorrison |
| Formula | C23H27FN4O3 |
| Net Charge | 0 |
| Average Mass | 426.484 |
| Monoisotopic Mass | 426.20672 |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Biological Roles: | serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. |
| Applications: | neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. psychotropic drug A loosely defined grouping of drugs that have effects on psychological function. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. second generation antipsychotic Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| paliperidone (CHEBI:82978) has part (R)-paliperidone (CHEBI:83806) |
| paliperidone (CHEBI:82978) has part (S)-paliperidone (CHEBI:83805) |
| paliperidone (CHEBI:82978) has role dopaminergic antagonist (CHEBI:48561) |
| paliperidone (CHEBI:82978) has role drug metabolite (CHEBI:49103) |
| paliperidone (CHEBI:82978) has role H1-receptor antagonist (CHEBI:37955) |
| paliperidone (CHEBI:82978) has role neuroprotective agent (CHEBI:63726) |
| paliperidone (CHEBI:82978) has role psychotropic drug (CHEBI:35471) |
| paliperidone (CHEBI:82978) has role second generation antipsychotic (CHEBI:65191) |
| paliperidone (CHEBI:82978) has role serotonergic antagonist (CHEBI:48279) |
| paliperidone (CHEBI:82978) has role α-adrenergic antagonist (CHEBI:37890) |
| paliperidone (CHEBI:82978) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one |
| INN | Source |
|---|---|
| paliperidone | KEGG DRUG |
| Synonyms | Source |
|---|---|
| Ro-76477 | DrugBank |
| 9-Hydroxyrisperidone | DrugBank |
| RO76477 | ChemIDplus |
| rac-paliperidone | ChemIDplus |
| racemic paliperidone | ChemIDplus |
| 9-hydroxy-risperidone | ChemIDplus |
| Brand Name | Source |
|---|---|
| Invega | KEGG DRUG |
| Manual Xrefs | Databases |
|---|---|
| D05339 | KEGG DRUG |
| DB01267 | DrugBank |
| HMDB0015396 | HMDB |
| Paliperidone | Wikipedia |
| Registry Numbers | Sources |
|---|---|
| Reaxys:8808385 | Reaxys |
| CAS:144598-75-4 | KEGG DRUG |
| CAS:144598-75-4 | ChemIDplus |
| Citations |
|---|