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CHEBI:82864 - flutrimazole

ChEBI IDCHEBI:82864
ChEBI Nameflutrimazole
Stars
DefinitionAn imidazole antifungal agent that is imidazole in which the hydrogen attached to the nitrogen is replaced by a 2,4'-difluorotrityl group. A topical antifungal agent which displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts.
Last Modified22 February 2017
Submittertmorrison
DownloadsMolfile
FormulaC22H16F2N2
Net Charge0
Average Mass346.380
Monoisotopic Mass346.12815
SMILESFc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1
InChIInChI=1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H
InChIKeyQHMWCHQXCUNUAK-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor  An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of EC 1.14.13.70 (sterol 14α-demethylase).
antifungal drug  Any antifungal agent used to prevent or treat fungal infections in humans or animals.
antifungal agent  An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
antifungal agent  An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
Application:
antifungal drug  Any antifungal agent used to prevent or treat fungal infections in humans or animals.
ChEBI Ontology
Outgoing Relation(s)
flutrimazole (CHEBI:82864) has role EC 1.14.13.70 (sterol 14α-demethylase) inhibitor (CHEBI:77884)
flutrimazole (CHEBI:82864) is a imidazole antifungal drug (CHEBI:87069)
flutrimazole (CHEBI:82864) is a imidazoles (CHEBI:24780)
flutrimazole (CHEBI:82864) is a monofluorobenzenes (CHEBI:83575)
IUPAC Name 
1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
INNs  Source
flutrimazoleKEGG DRUG
flutrimazolumChemIDplus
flutrimazolChemIDplus
flutrimazoleChemIDplus
Synonyms  Source
1-(o-Fluoro-alpha-(p-fluorophenyl)-alpha-phenylbenzyl)imidazoleChemIDplus
1-(2,4'-difluorotrityl)imidazoleChEBI
Manual XrefsDatabases
D07193KEGG DRUG
FlutrimazoleWikipedia
WO9920271Patent
1227DrugCentral
Registry NumbersSources
Reaxys:5383184Reaxys
CAS:119006-77-8KEGG DRUG
CAS:119006-77-8ChemIDplus
Citations