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CHEBI:8228 - pioglitazone
| Formula | C19H20N2O3S |
| Net Charge | 0 |
| Average Mass | 356.447 |
| Monoisotopic Mass | 356.11946 |
| SMILES | CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 |
| InChI | InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23) |
| InChIKey | HYAFETHFCAUJAY-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Biological Roles: | xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. PPARgamma agonist A PPAR modulator which activates the peroxisome proliferator-activated receptor-γ. ferroptosis inhibitor Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms. insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. EC 2.7.1.33 (pantothenate kinase) inhibitor An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of pantothenate kinase (EC 2.7.1.33). antiviral agent A substance that destroys or inhibits replication of viruses. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor An EC 6.2.1.* (acid-thiol ligase) inhibitor that interferes with the action of a long-chain-fatty-acid—CoA ligase (EC 6.2.1.3). anti-obesity agent Any substance which is used to reduce or control weight. |
| Applications: | gastrointestinal drug A drug used for its effects on the gastrointestinal system, e.g. controlling gastric acidity, regulating gastrointestinal motility and water flow, and improving digestion. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. anti-asthmatic agent Any compound that has anti-asthmatic effects. antiparkinson drug A drug used in the treatment of Parkinson's disease. insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. hypoglycemic agent A drug which lowers the blood glucose level. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antirheumatic drug A drug used to treat rheumatoid arthritis. antiatherosclerotic agent A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent. anti-inflammatory agent Any compound that has anti-inflammatory effects. cardioprotective agent Any protective agent that is able to prevent damage to the heart. antipsoriatic A drug used to treat psoriasis. antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. anti-anaemic agent A compound which increases either the number of red cells or the amount of haemoglobin in the blood. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| pioglitazone (CHEBI:8228) has role anti-anaemic agent (CHEBI:75835) |
| pioglitazone (CHEBI:8228) has role anti-asthmatic agent (CHEBI:65023) |
| pioglitazone (CHEBI:8228) has role anti-HIV agent (CHEBI:64946) |
| pioglitazone (CHEBI:8228) has role anti-inflammatory agent (CHEBI:67079) |
| pioglitazone (CHEBI:8228) has role anti-obesity agent (CHEBI:74518) |
| pioglitazone (CHEBI:8228) has role antiatherosclerotic agent (CHEBI:145947) |
| pioglitazone (CHEBI:8228) has role antidepressant (CHEBI:35469) |
| pioglitazone (CHEBI:8228) has role antihypertensive agent (CHEBI:35674) |
| pioglitazone (CHEBI:8228) has role antiinfective agent (CHEBI:35441) |
| pioglitazone (CHEBI:8228) has role antineoplastic agent (CHEBI:35610) |
| pioglitazone (CHEBI:8228) has role antiparkinson drug (CHEBI:48407) |
| pioglitazone (CHEBI:8228) has role antipsoriatic (CHEBI:50748) |
| pioglitazone (CHEBI:8228) has role antirheumatic drug (CHEBI:35842) |
| pioglitazone (CHEBI:8228) has role antiviral agent (CHEBI:22587) |
| pioglitazone (CHEBI:8228) has role cardioprotective agent (CHEBI:77307) |
| pioglitazone (CHEBI:8228) has role cardiovascular drug (CHEBI:35554) |
| pioglitazone (CHEBI:8228) has role EC 2.7.1.33 (pantothenate kinase) inhibitor (CHEBI:77194) |
| pioglitazone (CHEBI:8228) has role EC 6.2.1.3 (long-chain-fatty-acid—CoA ligase) inhibitor (CHEBI:83157) |
| pioglitazone (CHEBI:8228) has role ferroptosis inhibitor (CHEBI:173084) |
| pioglitazone (CHEBI:8228) has role gastrointestinal drug (CHEBI:55324) |
| pioglitazone (CHEBI:8228) has role geroprotector (CHEBI:176497) |
| pioglitazone (CHEBI:8228) has role hypoglycemic agent (CHEBI:35526) |
| pioglitazone (CHEBI:8228) has role immunosuppressive agent (CHEBI:35705) |
| pioglitazone (CHEBI:8228) has role insulin-sensitizing drug (CHEBI:50864) |
| pioglitazone (CHEBI:8228) has role PPARγ agonist (CHEBI:71554) |
| pioglitazone (CHEBI:8228) has role xenobiotic (CHEBI:35703) |
| pioglitazone (CHEBI:8228) is a aromatic ether (CHEBI:35618) |
| pioglitazone (CHEBI:8228) is a pyridines (CHEBI:26421) |
| pioglitazone (CHEBI:8228) is a thiazolidinediones (CHEBI:50990) |
| Incoming Relation(s) |
| hydroxypioglitazone (CHEBI:82937) has functional parent pioglitazone (CHEBI:8228) |
| IUPAC Name |
|---|
| 5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione |
| INNs | Source |
|---|---|
| pioglitazona | ChemIDplus |
| pioglitazone | ChemIDplus |
| pioglitazonum | ChemIDplus |
| Synonyms | Source |
|---|---|
| (±)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione | ChemIDplus |
| AD-4833 | ChEMBL |
| Duetact | ChEMBL |
| Pioglitazone | KEGG COMPOUND |
| U-72107 | ChEMBL |
| Zactos | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| 2179 | DrugCentral |
| 4663 | ChemSpider |
| C07675 | KEGG COMPOUND |
| D08378 | KEGG DRUG |
| DB01132 | DrugBank |
| EP193256 | Patent |
| HMDB0015264 | HMDB |
| LSM-1592 | LINCS |
| Pioglitazone | Wikipedia |
| US4687777 | Patent |
| Registry Numbers | Sources |
|---|---|
| Reaxys:3595485 | Reaxys |
| CAS:111025-46-8 | ChemIDplus |
| CAS:111025-46-8 | KEGG COMPOUND |
| Citations |
|---|