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CHEBI:27953 - physostigmine
| Formula | C15H21N3O2 |
| Net Charge | 0 |
| Average Mass | 275.352 |
| Monoisotopic Mass | 275.16338 |
| SMILES | [H][C@]12N(C)CC[C@@]1(C)c1cc(OC(=O)NC)ccc1N2C |
| InChI | InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1 |
| InChIKey | PIJVFDBKTWXHHD-HIFRSBDPSA-N |
| Roles Classification |
|---|
| Biological Roles: | analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. EC 3.1.1.8 (cholinesterase) inhibitor An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8). insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). miotic An agent causing contraction of the pupil of the eye. Because the size of the pupil is under the antagonistic control of the sympathetic and parasympathetic systems, drugs affecting either system can cause miosis. Drugs that mimic or potentiate the parasympathetic input to the circular constrictor muscle and drugs that inhibit sympathetic input to the radial dilator muscle tend to contract the pupils. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| Applications: | analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antidote to curare poisoning A role borne by a molecule that acts to counteract or neutralize the deleterious effects of curare. insulin-sensitizing drug An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). antiglaucoma drug Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye. miotic An agent causing contraction of the pupil of the eye. Because the size of the pupil is under the antagonistic control of the sympathetic and parasympathetic systems, drugs affecting either system can cause miosis. Drugs that mimic or potentiate the parasympathetic input to the circular constrictor muscle and drugs that inhibit sympathetic input to the radial dilator muscle tend to contract the pupils. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| physostigmine (CHEBI:27953) has role analgesic (CHEBI:35480) |
| physostigmine (CHEBI:27953) has role antidote to curare poisoning (CHEBI:74530) |
| physostigmine (CHEBI:27953) has role antiglaucoma drug (CHEBI:39456) |
| physostigmine (CHEBI:27953) has role EC 3.1.1.8 (cholinesterase) inhibitor (CHEBI:37733) |
| physostigmine (CHEBI:27953) has role insulin-sensitizing drug (CHEBI:50864) |
| physostigmine (CHEBI:27953) has role miotic (CHEBI:51068) |
| physostigmine (CHEBI:27953) is a carbamate ester (CHEBI:23003) |
| physostigmine (CHEBI:27953) is a indole alkaloid (CHEBI:38958) |
| Incoming Relation(s) |
| physostigmine salicylate (CHEBI:48883) has part physostigmine (CHEBI:27953) |
| IUPAC Name |
|---|
| (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate |
| Synonyms | Source |
|---|---|
| Antilirium | ChemIDplus |
| Eserin | ChEMBL |
| Eserine | KEGG DRUG |
| Eserinum | ChEMBL |
| MCV-4484 | ChEMBL |
| NSC-30782 | ChEMBL |
| Citations |
|---|