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CHEBI:80144 - kinetensin

ChEBI IDCHEBI:80144
ChEBI Namekinetensin
Stars
DefinitionAn oligopeptide comprising of nine amino acids with sequence L-Ile-L-Ala-L-Arg-L-Arg-L-His-L-Pro-L-Tyr-L-Phe-L-Leu. It was originally isolated from pepsin-treated human plasma and shares some sequence homology with the C-terminal end of neurotensin. It is a potent histamine releaser and may serve as an inflammatory mediator.
Last Modified20 April 2020
DownloadsMolfile
FormulaC56H85N17O11
Net Charge0
Average Mass1172.404
Monoisotopic Mass1171.66145
SMILESCC[C@H](C)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cncn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O
InChIInChI=1S/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/t32-,33-,38-,39-,40-,41-,42-,43-,44-,45-/m0/s1
InChIKeyPANUJGMSOSQAAY-IHXGQVBNSA-N
Species of MetaboliteComponentSourceComments
Homo sapiens (ncbitaxon:9606) blood plasma (BTO_0000131) PubMed (2437111)
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
histamine releasing agent  Any substance that can induce the release of histamine from mast cells.
human metabolite  Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
ChEBI Ontology
Outgoing Relation(s)
kinetensin (CHEBI:80144) has role histamine releasing agent (CHEBI:75298)
kinetensin (CHEBI:80144) has role human metabolite (CHEBI:77746)
kinetensin (CHEBI:80144) is a oligopeptide (CHEBI:25676)
kinetensin (CHEBI:80144) is conjugate base of kinetensin(2+) (CHEBI:147364)
Incoming Relation(s)
kinetensin(2+) (CHEBI:147364) is conjugate acid of kinetensin (CHEBI:80144)
IUPAC Name 
L-isoleucyl-L-alanyl-L-arginyl-L-arginyl-L-histidyl-L-prolyl-L-tyrosyl-L-phenylalanyl-L-leucine
Synonyms  Source
L-Ile-L-Ala-L-Arg-L-Arg-L-His-L-Pro-L-Tyr-L-Phe-L-LeuChEBI
Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-LeuKEGG COMPOUND
kinetensin (human)ChEBI
IARRHPYFLChEBI
I-A-R-R-H-P-Y-F-LChEBI
H-Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu-OHChEBI
Manual XrefsDatabases
C15872KEGG COMPOUND
FDB029235FooDB
HMDB0012988HMDB
WO2009040022Patent
Registry NumbersSources
CAS:103131-69-7ChemIDplus
Citations