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CHEBI:80128 - angiotensin (1-9)

ChEBI IDCHEBI:80128
ChEBI Nameangiotensin (1-9)
Stars
DefinitionA nine amino acid peptide which is formed when angiotensin converting enzyme 2 (ACE2) hydrolyzes the carboxy terminal leucine from angiotensin I. It is a anti-cardiac hypertrophy agent.
Last Modified9 April 2020
DownloadsMolfile
FormulaC56H78N16O13
Net Charge0
Average Mass1183.339
Monoisotopic Mass1182.59343
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cncn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cncn1)C(=O)O
InChIInChI=1S/C56H78N16O13/c1-5-31(4)46(71-50(79)40(22-33-15-17-36(73)18-16-33)67-52(81)45(30(2)3)70-48(77)38(13-9-19-62-56(58)59)65-47(76)37(57)25-44(74)75)53(82)68-41(23-34-26-60-28-63-34)54(83)72-20-10-14-43(72)51(80)66-39(21-32-11-7-6-8-12-32)49(78)69-42(55(84)85)24-35-27-61-29-64-35/h6-8,11-12,15-18,26-31,37-43,45-46,73H,5,9-10,13-14,19-25,57H2,1-4H3,(H,60,63)(H,61,64)(H,65,76)(H,66,80)(H,67,81)(H,68,82)(H,69,78)(H,70,77)(H,71,79)(H,74,75)(H,84,85)(H4,58,59,62)/t31-,37-,38-,39-,40-,41-,42-,43-,45-,46-/m0/s1
InChIKeyLJXGOQOPNPFXFT-JWRYNVNRSA-N
Species of MetaboliteComponentSourceComments
Rattus norvegicus (ncbitaxon:10116) - PubMed (26988149) Identified in the renal arteries isolated from Wistar Kyoto rats.
Homo sapiens (ncbitaxon:9606) blood plasma (BTO_0000131) PubMed (2170511)
Roles Classification
Chemical Roles:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
rat metabolite  Any mammalian metabolite produced during a metabolic reaction in rat (Rattus norvegicus).
human metabolite  Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
hormone  Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
Applications:
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
cardioprotective agent  Any protective agent that is able to prevent damage to the heart.
ChEBI Ontology
Outgoing Relation(s)
angiotensin (1-9) (CHEBI:80128) has role antihypertensive agent (CHEBI:35674)
angiotensin (1-9) (CHEBI:80128) has role cardioprotective agent (CHEBI:77307)
angiotensin (1-9) (CHEBI:80128) has role human metabolite (CHEBI:77746)
angiotensin (1-9) (CHEBI:80128) has role rat metabolite (CHEBI:86264)
angiotensin (1-9) (CHEBI:80128) is a angiotensin (CHEBI:48433)
angiotensin (1-9) (CHEBI:80128) is tautomer of angiotensin (1-9) dizwitterion (CHEBI:147351)
Incoming Relation(s)
angiotensin (1-9) dizwitterion (CHEBI:147351) is tautomer of angiotensin (1-9) (CHEBI:80128)
IUPAC Name 
L-α-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidine
Synonyms  Source
L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe-L-HisChEBI
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-HisChEBI
angiotensin-(1-9)ChEBI
ang-(1-9)ChEBI
des-Leu angiotensin IChEBI
D-R-V-Y-I-H-P-F-HChEBI
Manual XrefsDatabases
C15851KEGG COMPOUND
Registry NumbersSources
CAS:34273-12-6ChEBI
Citations