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CHEBI:79090 - SB-202190

ChEBI IDCHEBI:79090
ChEBI NameSB-202190
Stars
DefinitionA member of the class of imidazoles that is 1H-imidazole in which the hydrogens at positions 2, 4, and 5 are replaced by 4-hydroxyphenyl, pyridin-4-yl, and 4-fluorophenyl groups, respectively. It is a widely used inhibitor of mitogen-activated protein kinase (MAPK) α and β.
Last Modified9 July 2014
SubmitterGareth Owen
DownloadsMolfile
FormulaC20H14FN3O
Net Charge0
Average Mass331.350
Monoisotopic Mass331.11209
SMILESOc1ccc(-c2nc(-c3ccncc3)c(-c3ccc(F)cc3)n2)cc1
InChIInChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
InChIKeyQHKYPYXTTXKZST-UHFFFAOYSA-N
Roles Classification
Biological Roles:
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24).
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
ChEBI Ontology
Outgoing Relation(s)
SB-202190 (CHEBI:79090) has role apoptosis inducer (CHEBI:68495)
SB-202190 (CHEBI:79090) has role EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor (CHEBI:79091)
SB-202190 (CHEBI:79090) is a imidazoles (CHEBI:24780)
SB-202190 (CHEBI:79090) is a organofluorine compound (CHEBI:37143)
SB-202190 (CHEBI:79090) is a phenols (CHEBI:33853)
SB-202190 (CHEBI:79090) is a pyridines (CHEBI:26421)
IUPAC Name 
4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
Synonyms  Source
SB 202190ChemIDplus
SB202190ChEBI
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazoleChemIDplus
Registry NumbersSources
Reaxys:10467168Reaxys
CAS:152121-30-7ChemIDplus
Citations